Protein Information

Cytoscape View


UniProt AC / UniProt ID O75821 / EIF3G_HUMAN
Protein Name Eukaryotic translation initiation factor 3 subunit G
Gene Name Name: EIF3G
Synonyms:EIF3S4;
Organism Homo sapiens (Human)

PRO ID PR:O75821
DAG View
PRO Name eukaryotic translation initiation factor 3 subunit G (human)
Definition A eukaryotic translation initiation factor 3 subunit G that is encoded in the genome of human.
Short Label hEIF3G
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75821 (EIF3G) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T3 Phosphorylation PhosphoSitePlus
S8 Phosphorylation PhosphoSitePlus   UniProt 23186163
K9 Ubiquitination PhosphoSitePlus
S11 Phosphorylation PhosphoSitePlus   UniProt 24275569
K24 Ubiquitination PhosphoSitePlus
C25 S-Nitrosylation dbSNO 26338901
T27 Phosphorylation PhosphoSitePlus
T38 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 23186163, 20058876, ...19664995, 18669648, 19690332, 20068231
T41 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 17322306, 17287340, ...20230923, 20058876, 19664995, 18452278, 19651622, 18669648, 20068231, 19690332, 17322308
S42 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 18491316, 17287340, ...20230923, 15302935, 20058876, 19664995, 18452278, 19651622, 18669648, 20068231, 18707149, 19690332, 17322308
K57 Ubiquitination PhosphoSitePlus
K65 Ubiquitination PhosphoSitePlus
Y70 Phosphorylation PhosphoSitePlus
K71 Acetylation PhosphoSitePlus
K71 Ubiquitination PhosphoSitePlus
K78 Acetylation PhosphoSitePlus
T84 Phosphorylation PhosphoSitePlus
K94 Methylation PhosphoSitePlus
S108 Phosphorylation PhosphoSitePlus
S123 Phosphorylation PhosphoSitePlus
S127 Phosphorylation PhosphoSitePlus
K148 Ubiquitination PhosphoSitePlus
K161 Acetylation PhosphoSitePlus
K161 Ubiquitination PhosphoSitePlus
K172 Acetylation PhosphoSitePlus
K180 Ubiquitination PhosphoSitePlus
S189 Phosphorylation PhosphoSitePlus   UniProt 24275569
T190 Phosphorylation PhosphoSitePlus
K193 Acetylation PhosphoSitePlus
K193 Ubiquitination PhosphoSitePlus
K195 Ubiquitination PhosphoSitePlus
T206 Phosphorylation PhosphoSitePlus
K209 Ubiquitination PhosphoSitePlus
K212 Ubiquitination PhosphoSitePlus
Y213 Phosphorylation PhosphoSitePlus
S217 Phosphorylation PhosphoSitePlus
S223 Phosphorylation PhosphoSitePlus   UniProt 23186163
R225 Methylation PhosphoSitePlus
T240 Phosphorylation PhosphoSitePlus
S264 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S266 Phosphorylation HPRD   phospho.ELM 18669648
S286 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T3 I3 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
S8 L8 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
T41 N41 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K65 N65 Biomuta DOID:363 / uterine cancer [ tcga ]
K71 R71 Biomuta DOID:363 / uterine cancer [ tcga ]
T84 I84 Biomuta DOID:3070 / malignant glioma [ tcga ]
S108 T108 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]