iPTMnet Report for O75807 (PPP1R15A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O75807 / PR15A_HUMAN
Protein Name Protein phosphatase 1 regulatory subunit 15A
Gene Name Name: PPP1R15A
Synonyms:GADD34;
Organism Homo sapiens (Human)

PRO ID PR:O75807
DAG View
PRO Name protein phosphatase 1 regulatory subunit 15A (human)
Definition A protein phosphatase 1 regulatory subunit 15A that is encoded in the genome of human.
Short Label hPPP1R15A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75807 (PPP1R15A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S143 Phosphorylation PhosphoSitePlus   UniProt 23186163
S247 Phosphorylation PhosphoSitePlus
S249 Phosphorylation PhosphoSitePlus
Y262 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 24092754
S264 Phosphorylation PhosphoSitePlus
S307 Phosphorylation PhosphoSitePlus
K315 Acetylation PhosphoSitePlus
K322 Acetylation PhosphoSitePlus
Y391 Phosphorylation UniProt 24092754
T422 Phosphorylation PhosphoSitePlus
Y434 Phosphorylation UniProt 24092754
Y512 Phosphorylation UniProt 24092754
T540 Phosphorylation PhosphoSitePlus
K552 Ubiquitination PhosphoSitePlus
S559 Phosphorylation IEDB 35494241
Site PTM Type PTM Enzyme Score Source PMID
Y262 Phosphorylation HPRD 17287340
S264 Phosphorylation HPRD 17287340


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S249 F249 Biomuta DOID:4159 / skin cancer [ cosmic ]
K315 N315 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
Y391 C391 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
Y434 C434 Biomuta DOID:3571 / liver cancer [ cosmic ]