iPTMnet Report for O75792 (RNASEH2A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O75792 / RNH2A_HUMAN
Protein Name Ribonuclease H2 subunit A
Gene Name Name: RNASEH2A
Synonyms:RNASEHI,RNHIA;
Organism Homo sapiens (Human)

PRO ID PR:O75792
DAG View
PRO Name ribonuclease H2 subunit A (human)
Definition A ribonuclease H2 subunit A that is encoded in the genome of human.
Short Label hRNASEH2A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75792 (RNASEH2A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378, 22223895
S17 Phosphorylation PhosphoSitePlus
S18 Phosphorylation PhosphoSitePlus
K26 Ubiquitination PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
S68 Phosphorylation HPRD   PhosphoSitePlus 19664995, 20068231
K69 Acetylation PhosphoSitePlus
K69 Sumoylation PhosphoSitePlus
K69 Ubiquitination PhosphoSitePlus
T86 Phosphorylation HPRD 20068231
T103 Phosphorylation HPRD 20068231
K165 Ubiquitination PhosphoSitePlus
K167 Ubiquitination PhosphoSitePlus
Y172 Phosphorylation PhosphoSitePlus
C181 Methylation IEDB 31844290
K183 Ubiquitination PhosphoSitePlus
K192 Ubiquitination PhosphoSitePlus
K198 Ubiquitination PhosphoSitePlus
T204 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
Y206 Phosphorylation PhosphoSitePlus
S208 Phosphorylation PhosphoSitePlus
Y210 Phosphorylation PhosphoSitePlus
K215 Ubiquitination PhosphoSitePlus
T216 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
K221 Methylation PhosphoSitePlus
K221 Ubiquitination PhosphoSitePlus
S237 Phosphorylation PhosphoSitePlus
K247 Ubiquitination PhosphoSitePlus
K267 Ubiquitination PhosphoSitePlus
S270 Phosphorylation PhosphoSitePlus
Y271 Phosphorylation PhosphoSitePlus
S277 Phosphorylation PhosphoSitePlus   UniProt 23186163
R286 Methylation PhosphoSitePlus
R291 Methylation PhosphoSitePlus
T297 Phosphorylation PhosphoSitePlus
S298 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K69 N69 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K221 R221 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
R286 Q286 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ icgc ]
R291 C291 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R291 H291 Biomuta DOID:1612 / breast cancer [ cosmic ]
S298 R298 Biomuta DOID:1324 / lung cancer [ cosmic ]
S298 I298 Biomuta DOID:1793 / pancreatic cancer [ icgc ]