Protein Information

Cytoscape View


UniProt AC / UniProt ID O75791 / GRAP2_HUMAN
Protein Name GRB2-related adapter protein 2
Gene Name Name: GRAP2
Synonyms:GADS,GRB2L,GRID;
Organism Homo sapiens (Human)

PRO ID PR:O75791
DAG View
PRO Name GRB2-related adapter protein 2 (human)
Definition A GRB2-related adapter protein 2 that is encoded in the genome of human.
Short Label hGRAP2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75791 (GRAP2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K36 Ubiquitination PhosphoSitePlus
S41 Phosphorylation PhosphoSitePlus
Y45 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19690332, 15144186
K48 Ubiquitination PhosphoSitePlus
K57 Ubiquitination PhosphoSitePlus
K106 Acetylation PhosphoSitePlus   UniProt 19608861
K112 Ubiquitination PhosphoSitePlus
K121 Ubiquitination PhosphoSitePlus
K127 Ubiquitination PhosphoSitePlus
Y131 Phosphorylation PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
S159 Phosphorylation PhosphoSitePlus
S164 Phosphorylation PhosphoSitePlus
S181 Phosphorylation PhosphoSitePlus
S187 Phosphorylation PhosphoSitePlus
T192 Phosphorylation PhosphoSitePlus
Y207 Phosphorylation PhosphoSitePlus
Y222 Phosphorylation PhosphoSitePlus
R233 Methylation PhosphoSitePlus
S236 Phosphorylation PhosphoSitePlus
T246 Phosphorylation PhosphoSitePlus
S250 Phosphorylation PhosphoSitePlus
T262 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18088087, 15144186, 24275569, ...23186163, 12522270, 25452106
Y324 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y45 Phosphorylation HPRD 15144186
T262 Phosphorylation HPRD 12522270, 18088087, 15144186


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K36 N36 Biomuta DOID:1324 / lung cancer [ cosmic ]
K48 N48 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1612 / breast cancer [ cosmic, icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
S181 L181 Biomuta DOID:363 / uterine cancer [ tcga ]
R233 L233 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
T262 A262 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]