iPTMnet Report for O75781 (PALM)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O75781 / PALM_HUMAN
Protein Name Paralemmin-1 precursor
Gene Name Name: PALM
Synonyms:KIAA0270;
Organism Homo sapiens (Human)

PRO ID PR:O75781
DAG View
PRO Name paralemmin-1 (human)
Definition A paralemmin that is encoded in the genome of human.
Short Label hPALM
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75781 (PALM) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378, 22223895
T59 Phosphorylation phospho.ELM 18669648
S62 Phosphorylation PhosphoSitePlus
K93 Ubiquitination PhosphoSitePlus
S116 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S124 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S138 Phosphorylation PhosphoSitePlus
T141 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
T145 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S152 Phosphorylation PhosphoSitePlus
T154 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S162 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S171 Phosphorylation PhosphoSitePlus
S189 Phosphorylation PhosphoSitePlus
S245 Phosphorylation PhosphoSitePlus
S249 Phosphorylation PhosphoSitePlus
Y305 Phosphorylation PhosphoSitePlus
K377 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T59 Phosphorylation HPRD 18669648
S116 Phosphorylation HPRD 19651622, 18669648, 20068231
S124 Phosphorylation HPRD 19413330, 19651622, 18669648, ...20068231
S138 Phosphorylation HPRD 17081983, 20068231
T141 Phosphorylation HPRD 19413330, 19651622, 18669648, ...15345747, 20068231
T145 Phosphorylation HPRD 19413330, 19651622, 18669648, ...15345747, 20068231
S152 Phosphorylation HPRD 20068231
T154 Phosphorylation HPRD 18669648, 20068231
S162 Phosphorylation HPRD 18669648, 19664994
S346 Phosphorylation HPRD 15345747
T367 Phosphorylation HPRD 15345747
S369 Phosphorylation HPRD 15345747
Site PTM Type PTM Enzyme Score Source PMID
T59 Phosphorylation HPRD 18669648
S116 Phosphorylation HPRD 19651622, 18669648, 20068231
S124 Phosphorylation HPRD 19413330, 19651622, 18669648, ...20068231
S138 Phosphorylation HPRD 17081983, 20068231
T141 Phosphorylation HPRD 19413330, 19651622, 18669648, ...17081983, 20068231
T145 Phosphorylation HPRD 19413330, 19651622, 18669648, ...17081983, 20068231
S152 Phosphorylation HPRD 20068231
T154 Phosphorylation HPRD 18669648, 20068231
S162 Phosphorylation HPRD 18669648, 19664994


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T59 M59 Biomuta DOID:9256 / colorectal cancer [ cosmic, cosmic, cosmic ] [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ]
T154 M154 Biomuta [ cosmic ] DOID:10283 / prostate cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S171 T171 Biomuta DOID:1612 / breast cancer [ cosmic ]
S171 L171 Biomuta DOID:4159 / skin cancer [ cosmic ]