iPTMnet Report for O75746 (SLC25A12)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O75746 / S2512_HUMAN
Protein Name Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial
Gene Name Name: SLC25A12
Synonyms:AGC1;
Organism Homo sapiens (Human)

PRO ID PR:O75746
DAG View
PRO Name electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial (human)
Definition An electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial that is encoded in the genome of human.
Short Label hSLC25A12
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75746 (SLC25A12) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 25489052, 22814378
K4 Ubiquitination PhosphoSitePlus
K55 Ubiquitination PhosphoSitePlus
S101 Phosphorylation PhosphoSitePlus
K112 Acetylation PhosphoSitePlus
S183 Phosphorylation PhosphoSitePlus
T188 Phosphorylation PhosphoSitePlus
T249 Phosphorylation PhosphoSitePlus
K250 Ubiquitination PhosphoSitePlus
S256 O-Glycosylation GlyGen 30379171, 28510447
Y369 Phosphorylation PhosphoSitePlus
K370 Methylation PhosphoSitePlus
K377 Acetylation PhosphoSitePlus
K377 Methylation PhosphoSitePlus
K406 Ubiquitination PhosphoSitePlus
K451 Methylation PhosphoSitePlus
K482 Ubiquitination PhosphoSitePlus
K485 Ubiquitination PhosphoSitePlus
K578 Acetylation PhosphoSitePlus
Y606 Phosphorylation PhosphoSitePlus
T643 Phosphorylation PhosphoSitePlus
Y656 Phosphorylation PhosphoSitePlus
K661 Methylation PhosphoSitePlus
S662 Phosphorylation PhosphoSitePlus
T677 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K55 N55 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
T188 I188 Biomuta DOID:4159 / skin cancer [ cosmic ]
K377 N377 Biomuta DOID:1319 / brain cancer [ icgc ]
K485 T485 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S662 F662 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S662 Y662 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]