iPTMnet Report for O75717 (WDHD1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O75717 / WDHD1_HUMAN
Protein Name WD repeat and HMG-box DNA-binding protein 1
Gene Name Name: WDHD1
Synonyms:AND1;
Organism Homo sapiens (Human)

PRO ID PR:O75717
DAG View
PRO Name WD repeat and HMG-box DNA-binding protein 1 (human)
Definition A WD repeat and HMG-box DNA-binding protein 1 that is encoded in the genome of human.
Short Label hWDHD1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75717 (WDHD1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T4 Phosphorylation PhosphoSitePlus
T30 Phosphorylation PhosphoSitePlus
S33 Phosphorylation PhosphoSitePlus
K49 Ubiquitination PhosphoSitePlus
K56 Ubiquitination PhosphoSitePlus
K63 Ubiquitination PhosphoSitePlus
K66 Ubiquitination PhosphoSitePlus
K108 Ubiquitination PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
S126 Phosphorylation PhosphoSitePlus
S127 Phosphorylation PhosphoSitePlus
K130 Ubiquitination PhosphoSitePlus
T131 Phosphorylation PhosphoSitePlus
K187 Ubiquitination PhosphoSitePlus
K197 Ubiquitination PhosphoSitePlus
K200 Sumoylation PhosphoSitePlus
K200 Ubiquitination PhosphoSitePlus
K208 Ubiquitination PhosphoSitePlus
K272 Ubiquitination PhosphoSitePlus
C285 Methylation IEDB 31844290
S307 Phosphorylation PhosphoSitePlus
K309 Ubiquitination PhosphoSitePlus
K314 Acetylation PhosphoSitePlus
K314 Ubiquitination PhosphoSitePlus
Y323 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S333 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332, 20068231
S348 Phosphorylation PhosphoSitePlus
S350 Phosphorylation phospho.ELM 18669648
S367 Phosphorylation PhosphoSitePlus
S374 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983, 19690332
S383 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 19690332, 20068231
S387 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
K390 Ubiquitination PhosphoSitePlus
S393 Phosphorylation PhosphoSitePlus
S394 Phosphorylation PhosphoSitePlus
K397 Sumoylation PhosphoSitePlus
S407 Phosphorylation PhosphoSitePlus
C457 Methylation IEDB 31844290
T591 Phosphorylation PhosphoSitePlus
K611 Ubiquitination PhosphoSitePlus
K671 Acetylation PhosphoSitePlus
K744 Ubiquitination PhosphoSitePlus
K759 Ubiquitination PhosphoSitePlus
K767 Ubiquitination PhosphoSitePlus
K774 Ubiquitination PhosphoSitePlus
Y799 Phosphorylation PhosphoSitePlus
S801 Phosphorylation PhosphoSitePlus
S803 Phosphorylation PhosphoSitePlus
K805 Ubiquitination PhosphoSitePlus
K811 Ubiquitination PhosphoSitePlus
S813 Phosphorylation PhosphoSitePlus
K819 Ubiquitination PhosphoSitePlus
T824 Phosphorylation UniProt 17525332
T826 Phosphorylation Q13535 (ATR) phospho.ELM   PhosphoSitePlus   RLIMS-P+   Signor   UniProt 17525332, 23186163, 26082189
K840 Sumoylation PhosphoSitePlus
K840 Ubiquitination PhosphoSitePlus
S846 Phosphorylation PhosphoSitePlus
T848 Phosphorylation PhosphoSitePlus
S853 Phosphorylation PhosphoSitePlus
S868 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 23186163, ...17081983
S886 Phosphorylation PhosphoSitePlus
K899 Ubiquitination PhosphoSitePlus
S906 Phosphorylation PhosphoSitePlus
S907 Phosphorylation PhosphoSitePlus
K915 Methylation PhosphoSitePlus
K915 Ubiquitination PhosphoSitePlus
S917 Phosphorylation PhosphoSitePlus   UniProt 23186163
S919 Phosphorylation PhosphoSitePlus   UniProt 23186163
S926 Phosphorylation PhosphoSitePlus
S932 Phosphorylation PhosphoSitePlus   UniProt 23186163
S958 Phosphorylation PhosphoSitePlus
K962 Acetylation PhosphoSitePlus   UniProt 19608861
K971 Ubiquitination PhosphoSitePlus
S977 Phosphorylation PhosphoSitePlus
Y978 Phosphorylation PhosphoSitePlus
S984 Phosphorylation PhosphoSitePlus   UniProt 21406692
T986 Phosphorylation PhosphoSitePlus
S1041 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15302935, 23186163
S1058 Phosphorylation PhosphoSitePlus
K1063 Acetylation PhosphoSitePlus
K1068 Acetylation PhosphoSitePlus
K1070 Acetylation PhosphoSitePlus
S1090 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
K1101 Acetylation PhosphoSitePlus
K1127 Acetylation PhosphoSitePlus
K1127 Sumoylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y323 Phosphorylation HPRD 18669648, 17081983
S333 Phosphorylation HPRD 18669648, 20068231
S350 Phosphorylation HPRD 18669648
S374 Phosphorylation HPRD 17081983, 18452278
S383 Phosphorylation HPRD 17322306, 18767875, 18452278, ...19651622, 18669648, 20068231
S387 Phosphorylation HPRD 18669648, 20068231
S801 Phosphorylation HPRD 20068231
S803 Phosphorylation HPRD 20068231
T826 Phosphorylation HPRD 17525332, 18077418
S868 Phosphorylation HPRD 19413330, 17081983, 19664995, ...18452278, 19651622, 18669648
S919 Phosphorylation HPRD 20068231
S958 Phosphorylation HPRD 20068231
S1041 Phosphorylation HPRD 15302935
S1090 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
Y200 Phosphorylation HPRD 18669648, 17081983
S210 Phosphorylation HPRD 18669648, 20068231
S227 Phosphorylation HPRD 18669648
S251 Phosphorylation HPRD 17081983, 18452278
S260 Phosphorylation HPRD 17322306, 18767875, 18452278, ...19651622, 18669648, 20068231
S264 Phosphorylation HPRD 18669648, 20068231
S678 Phosphorylation HPRD 20068231
S680 Phosphorylation HPRD 20068231
T703 Phosphorylation HPRD 17525332, 18077418
S745 Phosphorylation HPRD 19413330, 17081983, 19664995, ...18452278, 19651622, 18669648
S796 Phosphorylation HPRD 20068231
S835 Phosphorylation HPRD 20068231
S918 Phosphorylation HPRD 15302935
S967 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K49 M49 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
K56 N56 Biomuta DOID:363 / uterine cancer [ icgc ]
K63 R63 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S126 R126 Biomuta DOID:3571 / liver cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
S127 N127 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K197 R197 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K208 I208 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S227 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S260 A260 Biomuta [ cosmic ]
K272 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S350 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S383 A383 Biomuta [ cosmic ]
S678 C678 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S680 C680 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K774 * Biomuta DOID:10534 / stomach cancer [ cosmic ]
S801 C801 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S803 C803 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S835 C835 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S886 L886 Biomuta DOID:4159 / skin cancer [ cosmic ]
S918 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S918 L918 Biomuta DOID:4159 / skin cancer [ cosmic ]
S958 C958 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K971 E971 Biomuta DOID:3571 / liver cancer [ cosmic ]
S1041 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S1041 L1041 Biomuta DOID:4159 / skin cancer [ cosmic ]