iPTMnet Report for O75688 (PPM1B)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O75688 / PPM1B_HUMAN
Protein Name Protein phosphatase 1B
Gene Name Name: PPM1B
Synonyms:PP2CB;
Organism Homo sapiens (Human)

PRO ID PR:O75688
DAG View
PRO Name protein phosphatase 1B (human)
Definition A protein phosphatase 1B that is encoded in the genome of human.
Short Label hPPM1B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75688 (PPM1B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
G2 Myristoylation UniProt 25255805
K12 Ubiquitination PhosphoSitePlus
K90 Ubiquitination PhosphoSitePlus
K103 Ubiquitination PhosphoSitePlus
K112 Ubiquitination PhosphoSitePlus
S121 Phosphorylation PhosphoSitePlus
S140 Phosphorylation PhosphoSitePlus
C163 S-Nitrosylation dbSNO 22178444
C172 S-Nitrosylation dbSNO 22178444
S195 Phosphorylation P17612 (PRKACA) PhosphoSitePlus   RLIMS-P 23756813
S265 Phosphorylation PhosphoSitePlus
S296 Phosphorylation PhosphoSitePlus
K314 Ubiquitination PhosphoSitePlus
K326 Ubiquitination PhosphoSitePlus
S343 Phosphorylation PhosphoSitePlus
Y367 Phosphorylation PhosphoSitePlus
S376 Phosphorylation PhosphoSitePlus
S386 Phosphorylation PhosphoSitePlus   UniProt 24275569
K391 Ubiquitination PhosphoSitePlus
Y418 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S376 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K103 N103 Biomuta DOID:363 / uterine cancer [ icgc ]
S265 T265 Biomuta DOID:4159 / skin cancer [ cosmic ]
K326 R326 Biomuta DOID:1324 / lung cancer [ cosmic ]
S376 R376 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K391 * Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]