Protein Information

Cytoscape View


UniProt AC / UniProt ID O75676 / KS6A4_HUMAN
Protein Name Ribosomal protein S6 kinase alpha-4
Gene Name Name: RPS6KA4
Synonyms:MSK2;
Organism Homo sapiens (Human)

PRO ID PR:O75676
DAG View
PRO Name ribosomal protein S6 kinase alpha-4 (human)
Definition A ribosomal protein S6 kinase alpha-4 that is encoded in the genome of human.
Short Label hRPS6KA4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75676 (RPS6KA4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T22 Phosphorylation PhosphoSitePlus
K27 Ubiquitination PhosphoSitePlus
S29 Phosphorylation PhosphoSitePlus
K37 Ubiquitination PhosphoSitePlus
T41 Phosphorylation PhosphoSitePlus
Y44 Phosphorylation PhosphoSitePlus
K69 Ubiquitination PhosphoSitePlus
S87 Phosphorylation PhosphoSitePlus
K134 Ubiquitination PhosphoSitePlus
Y141 Phosphorylation PhosphoSitePlus
S183 Phosphorylation PhosphoSitePlus
K184 Ubiquitination PhosphoSitePlus
K191 Ubiquitination PhosphoSitePlus
T194 Phosphorylation PhosphoSitePlus
S196 Phosphorylation Q16539 (MAPK14) , O75676 (RPS6KA4) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 10806207, 19933278, 17429437
K313 Ubiquitination PhosphoSitePlus
S324 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   RLIMS-P 19933278
Y342 Phosphorylation PhosphoSitePlus
S343 Phosphorylation Q16539 (MAPK14) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 10806207
S347 Phosphorylation Q16539 (MAPK14) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18691976, 23186163, 10806207, ...19369195
Y359 Phosphorylation PhosphoSitePlus
S360 Phosphorylation Q16539 (MAPK14) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 10806207
S365 Phosphorylation PhosphoSitePlus
T376 Phosphorylation PhosphoSitePlus
K440 Ubiquitination PhosphoSitePlus
S502 Phosphorylation PhosphoSitePlus
K532 Ubiquitination PhosphoSitePlus
T542 Phosphorylation PhosphoSitePlus   UniProt 19369195, 23186163
K548 Ubiquitination PhosphoSitePlus
T568 Phosphorylation Q16539 (MAPK14) phospho.ELM   PhosphoSitePlus   Signor 10806207
S634 Phosphorylation PhosphoSitePlus   UniProt 18691976
K648 Ubiquitination PhosphoSitePlus
K661 Ubiquitination PhosphoSitePlus
K664 Sumoylation PhosphoSitePlus
K664 Ubiquitination PhosphoSitePlus
S678 Phosphorylation PhosphoSitePlus   UniProt 18691976, 24275569
S681 Phosphorylation phospho.ELM   PhosphoSitePlus 17192257
S682 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17192257
T687 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 11035004, ...19369195
K720 Ubiquitination PhosphoSitePlus
S721 Phosphorylation PhosphoSitePlus
K729 Ubiquitination PhosphoSitePlus
S737 Phosphorylation PhosphoSitePlus
R743 Methylation PhosphoSitePlus
S745 Phosphorylation PhosphoSitePlus   UniProt 18691976, 24275569
S772 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S196 Phosphorylation Q16539 (MAPK14) , Q02750 (MAP2K1) HPRD 10806207
S343 Phosphorylation Q02750 (MAP2K1) , Q16539 (MAPK14) HPRD 10806207, 18691976, 19651622, ...20068231
S347 Phosphorylation Q02750 (MAP2K1) , Q16539 (MAPK14) HPRD 10806207, 18691976, 19651622, ...16964243, 20068231
Y359 Phosphorylation HPRD 18691976
S360 Phosphorylation Q02750 (MAP2K1) , Q16539 (MAPK14) HPRD 10806207
S365 Phosphorylation HPRD 18691976
T568 Phosphorylation Q16539 (MAPK14) , Q02750 (MAP2K1) HPRD 10806207
S634 Phosphorylation HPRD 18691976
S678 Phosphorylation HPRD 18691976
S681 Phosphorylation HPRD 18691976, 20068231
S682 Phosphorylation HPRD 18691976, 18669648
T687 Phosphorylation O75676 (RPS6KA4) HPRD 18691976, 19664994, 17192257, ...18767875
S693 Phosphorylation HPRD 18691976
S737 Phosphorylation HPRD 18691976
S745 Phosphorylation HPRD 18691976
Site PTM Type PTM Enzyme Score Source PMID
S196 Phosphorylation Q02750 (MAP2K1) , Q16539 (MAPK14) HPRD 10806207
S343 Phosphorylation Q02750 (MAP2K1) , Q16539 (MAPK14) HPRD 10806207, 18691976, 19651622, ...20068231
S347 Phosphorylation Q02750 (MAP2K1) , Q16539 (MAPK14) HPRD 10806207, 18691976, 19651622, ...16964243, 20068231
Y359 Phosphorylation HPRD 18691976
S360 Phosphorylation Q16539 (MAPK14) , Q02750 (MAP2K1) HPRD 10806207
S365 Phosphorylation HPRD 18691976
T562 Phosphorylation Q02750 (MAP2K1) , Q16539 (MAPK14) HPRD 10806207
S628 Phosphorylation HPRD 18691976
S672 Phosphorylation HPRD 18691976
S675 Phosphorylation HPRD 18691976, 20068231
S676 Phosphorylation HPRD 18691976, 18669648
T681 Phosphorylation O75676 (RPS6KA4) HPRD 18691976, 19664994, 17192257, ...18767875
S687 Phosphorylation HPRD 18691976
S731 Phosphorylation HPRD 18691976
S739 Phosphorylation HPRD 18691976


O75676 (RPS6KA4) as PTM Enzyme



Substrate Site Score Source PMID
O75676 (RPS6KA4) S196 neXtProt   PhosphoSitePlus   Signor 10806207, 19933278, 17429437
O75676-2 (RPS6KA4) T681 HPRD 18691976, 19664994, 17192257, ...18767875
O75676-1 (RPS6KA4) T687 HPRD 18691976, 19664994, 17192257, ...18767875
P01100 (FOS) S362 Signor 8248197, 22187936
P05114 (HMGN1) S7 HPRD   neXtProt 20166139, 12773393, 11438671, ...17924679
P16220-1 (CREB1) S133 HPRD   neXtProt   PhosphoSitePlus   Signor 16517600, 18690222, 8688081, ...11909979, 11175347, 9687510, 9829964, 17668895, 17429437
P18846 (ATF1) S63 HPRD   neXtProt 8663317, 18690222, 11909979, ...20068231
Q04206 (RELA) S276 neXtProt   PhosphoSitePlus   Signor 19933278, 17183360


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T41 M41 Biomuta DOID:9256 / colorectal cancer [ tcga ]
Y44 H44 Biomuta DOID:1909 / melanoma [ cosmic ]
K313 N313 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
T542 M542 Biomuta DOID:1612 / breast cancer [ cosmic ]
T568 M568 Biomuta DOID:10283 / prostate cancer [ cosmic ]
T687 M687 Biomuta DOID:10534 / stomach cancer [ tcga ]
S737 C737 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
S772 P772 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]