iPTMnet Report for O75676 (RPS6KA4)
Protein Information
UniProt AC / UniProt ID | O75676 / KS6A4_HUMAN |
Protein Name | Ribosomal protein S6 kinase alpha-4 |
Gene Name | Name: RPS6KA4 Synonyms:MSK2; |
Organism | Homo sapiens (Human) |
PRO ID | PR:O75676 |
PRO Name | ribosomal protein S6 kinase alpha-4 (human) |
Definition | A ribosomal protein S6 kinase alpha-4 that is encoded in the genome of human. |
Short Label | hRPS6KA4 |
Category | organism-gene |
O75676 (RPS6KA4) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
T22 | Phosphorylation | score1 | PhosphoSitePlus | |||
K27 | Ubiquitination | score1 | PhosphoSitePlus | |||
S29 | Phosphorylation | score1 | PhosphoSitePlus | |||
K37 | Ubiquitination | score1 | PhosphoSitePlus | |||
T41 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y44 | Phosphorylation | score1 | PhosphoSitePlus | |||
K69 | Ubiquitination | score1 | PhosphoSitePlus | |||
S87 | Phosphorylation | score1 | PhosphoSitePlus | |||
K134 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y141 | Phosphorylation | score1 | PhosphoSitePlus | |||
S183 | Phosphorylation | score1 | PhosphoSitePlus | |||
K184 | Ubiquitination | score1 | PhosphoSitePlus | |||
K191 | Ubiquitination | score1 | PhosphoSitePlus | |||
T194 | Phosphorylation | score1 | PhosphoSitePlus | |||
S196 | Phosphorylation | Q16539 (MAPK14) , O75676 (RPS6KA4) | score4 | neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor | 10806207, 19933278, 17429437 | |
K313 | Ubiquitination | score1 | PhosphoSitePlus | |||
S324 | Phosphorylation | P68400 (CSNK2A1) | score3 | PhosphoSitePlus RLIMS-P | 19933278 | |
Y342 | Phosphorylation | score1 | PhosphoSitePlus | |||
S343 | Phosphorylation | Q16539 (MAPK14) | score3 | phospho.ELM PhosphoSitePlus RLIMS-P Signor | 10806207 | |
S347 | Phosphorylation | Q16539 (MAPK14) | score4 | phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt | 18691976, 23186163, 10806207, ... | |
Y359 | Phosphorylation | score1 | PhosphoSitePlus | |||
S360 | Phosphorylation | Q16539 (MAPK14) | score3 | phospho.ELM PhosphoSitePlus RLIMS-P Signor | 10806207 | |
S365 | Phosphorylation | score1 | PhosphoSitePlus | |||
T376 | Phosphorylation | score1 | PhosphoSitePlus | |||
K440 | Ubiquitination | score1 | PhosphoSitePlus | |||
S502 | Phosphorylation | score1 | PhosphoSitePlus | |||
K532 | Ubiquitination | score1 | PhosphoSitePlus | |||
T542 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 19369195, 23186163 | ||
K548 | Ubiquitination | score1 | PhosphoSitePlus | |||
T568 | Phosphorylation | Q16539 (MAPK14) | score3 | phospho.ELM PhosphoSitePlus Signor | 10806207 | |
S634 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 18691976 | ||
K648 | Ubiquitination | score1 | PhosphoSitePlus | |||
K661 | Ubiquitination | score1 | PhosphoSitePlus | |||
K664 | Sumoylation | score1 | PhosphoSitePlus | |||
K664 | Ubiquitination | score1 | PhosphoSitePlus | |||
S678 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 18691976, 24275569 | ||
S681 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 17192257 | ||
S682 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648, 17192257 | ||
T687 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus UniProt | 18691976, 23186163, 11035004, ... | ||
K720 | Ubiquitination | score1 | PhosphoSitePlus | |||
S721 | Phosphorylation | score1 | PhosphoSitePlus | |||
K729 | Ubiquitination | score1 | PhosphoSitePlus | |||
S737 | Phosphorylation | score1 | PhosphoSitePlus | |||
R743 | Methylation | score1 | PhosphoSitePlus | |||
S745 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 18691976, 24275569 | ||
S772 | Phosphorylation | score1 | PhosphoSitePlus |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S196 | Phosphorylation | Q16539 (MAPK14) , Q02750 (MAP2K1) | score1 | HPRD | 10806207 | |
S343 | Phosphorylation | Q02750 (MAP2K1) , Q16539 (MAPK14) | score2 | HPRD | 10806207, 18691976, 19651622, ... | |
S347 | Phosphorylation | Q02750 (MAP2K1) , Q16539 (MAPK14) | score2 | HPRD | 10806207, 18691976, 19651622, ... | |
Y359 | Phosphorylation | score0 | HPRD | 18691976 | ||
S360 | Phosphorylation | Q02750 (MAP2K1) , Q16539 (MAPK14) | score1 | HPRD | 10806207 | |
S365 | Phosphorylation | score0 | HPRD | 18691976 | ||
T568 | Phosphorylation | Q16539 (MAPK14) , Q02750 (MAP2K1) | score1 | HPRD | 10806207 | |
S634 | Phosphorylation | score0 | HPRD | 18691976 | ||
S678 | Phosphorylation | score0 | HPRD | 18691976 | ||
S681 | Phosphorylation | score0 | HPRD | 18691976, 20068231 | ||
S682 | Phosphorylation | score0 | HPRD | 18691976, 18669648 | ||
T687 | Phosphorylation | O75676 (RPS6KA4) | score0 | HPRD | 18691976, 19664994, 17192257, ... | |
S693 | Phosphorylation | score0 | HPRD | 18691976 | ||
S737 | Phosphorylation | score0 | HPRD | 18691976 | ||
S745 | Phosphorylation | score0 | HPRD | 18691976 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S196 | Phosphorylation | Q02750 (MAP2K1) , Q16539 (MAPK14) | score1 | HPRD | 10806207 | |
S343 | Phosphorylation | Q02750 (MAP2K1) , Q16539 (MAPK14) | score2 | HPRD | 10806207, 18691976, 19651622, ... | |
S347 | Phosphorylation | Q02750 (MAP2K1) , Q16539 (MAPK14) | score2 | HPRD | 10806207, 18691976, 19651622, ... | |
Y359 | Phosphorylation | score0 | HPRD | 18691976 | ||
S360 | Phosphorylation | Q16539 (MAPK14) , Q02750 (MAP2K1) | score1 | HPRD | 10806207 | |
S365 | Phosphorylation | score0 | HPRD | 18691976 | ||
T562 | Phosphorylation | Q02750 (MAP2K1) , Q16539 (MAPK14) | score1 | HPRD | 10806207 | |
S628 | Phosphorylation | score0 | HPRD | 18691976 | ||
S672 | Phosphorylation | score0 | HPRD | 18691976 | ||
S675 | Phosphorylation | score0 | HPRD | 18691976, 20068231 | ||
S676 | Phosphorylation | score0 | HPRD | 18691976, 18669648 | ||
T681 | Phosphorylation | O75676 (RPS6KA4) | score0 | HPRD | 18691976, 19664994, 17192257, ... | |
S687 | Phosphorylation | score0 | HPRD | 18691976 | ||
S731 | Phosphorylation | score0 | HPRD | 18691976 | ||
S739 | Phosphorylation | score0 | HPRD | 18691976 |
O75676 (RPS6KA4) as PTM Enzyme
Substrate | Site | Score | Source | PMID | |
---|---|---|---|---|---|
O75676 (RPS6KA4) | S196 | score4 | neXtProt PhosphoSitePlus Signor | 10806207, 19933278, 17429437 | |
O75676-2 (RPS6KA4) | T681 | score0 | HPRD | 18691976, 19664994, 17192257, ... | |
O75676-1 (RPS6KA4) | T687 | score0 | HPRD | 18691976, 19664994, 17192257, ... | |
P01100 (FOS) | S362 | score2 | Signor | 8248197, 22187936 | |
P05114 (HMGN1) | S7 | score4 | HPRD neXtProt | 20166139, 12773393, 11438671, ... | |
P16220 (CREB1) | S119 | score1 | Signor | 17668895 | |
P16220-1 (CREB1) | S133 | score2 | HPRD | 11175347, 9687510, 8688081, ... | |
P18846-1 (ATF1) | S63 | score4 | HPRD neXtProt | 8663317, 18690222, 11909979, ... | |
Q04206 (RELA) | S276 | score4 | neXtProt PhosphoSitePlus Signor | 19933278, 17183360 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
K27 | N27 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
T41 | M41 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
Y44 | H44 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
K191 | * | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
S196 | F196 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
K313 | N313 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] | |
S324 | P324 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
T542 | M542 | Biomuta | DOID:1612 / breast cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ] | |
T568 | M568 | Biomuta | DOID:10283 / prostate cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ] | |
S682 | L682 | Biomuta | [ cosmic ] | |
S693 | F693 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
S737 | C737 | Biomuta | DOID:11054 / urinary bladder cancer [ icgc ] | |
S772 | P772 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] |