Protein Information

Cytoscape View

UniProt AC / UniProt ID O75674 / TM1L1_HUMAN
Protein Name TOM1-like protein 1
Gene Name Name: TOM1L1
Organism Homo sapiens (Human)

PRO ID PR:O75674
DAG View
PRO Name TOM1-like protein 1 (human)
Definition A TOM1-like protein 1 that is encoded in the genome of human.
Short Label hTOM1L1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

O75674 (TOM1L1) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
K5 Ubiquitination PhosphoSitePlus
S6 Phosphorylation PhosphoSitePlus
Y11 Phosphorylation PhosphoSitePlus
K93 Acetylation PhosphoSitePlus
K98 Ubiquitination PhosphoSitePlus
K103 Ubiquitination PhosphoSitePlus
Y109 Phosphorylation PhosphoSitePlus
K148 Ubiquitination PhosphoSitePlus
K149 Ubiquitination PhosphoSitePlus
K191 Ubiquitination PhosphoSitePlus
S207 Phosphorylation PhosphoSitePlus
K241 Ubiquitination PhosphoSitePlus
K298 Methylation PhosphoSitePlus
K298 Ubiquitination PhosphoSitePlus
K301 Ubiquitination PhosphoSitePlus
S311 Phosphorylation PhosphoSitePlus
S314 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332
S321 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 26899482, 18669648, 19690332, ...24275569
S323 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 17525332, 23186163, 26899482, ...18669648, 24275569, 19690332, 20068231
S342 Phosphorylation PhosphoSitePlus
Y392 Phosphorylation PhosphoSitePlus
Y441 Phosphorylation PhosphoSitePlus
Y442 Phosphorylation PhosphoSitePlus
T455 Phosphorylation PhosphoSitePlus
T456 Phosphorylation PhosphoSitePlus
Y460 Phosphorylation PhosphoSitePlus   RLIMS-P 19798056
Site PTM Type PTM Enzyme Score Source PMID
S314 Phosphorylation HPRD 17525332
S321 Phosphorylation HPRD 18669648
S323 Phosphorylation HPRD 19413330, 17525332, 18669648, ...20068231
Y460 Phosphorylation P06241 (FYN) HPRD 11711534

PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O75674 (TOM1L1) S321 Q9H0E2 (TOLLIP) unknown eFIP 26899482
Phosphorylation O75674 (TOM1L1) Y460 P62993 (GRB2) unknown eFIP 19798056

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y11 * Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
K191 * Biomuta DOID:9256 / colorectal cancer [ icgc ]
S323 I323 Biomuta DOID:3953 / adrenal gland cancer [ tcga ]
T455 I455 Biomuta DOID:5041 / esophageal cancer [ icgc ]
T456 A456 Biomuta DOID:1324 / lung cancer [ tcga ]