iPTMnet Report for O75600 (GCAT)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O75600 / KBL_HUMAN
Protein Name 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial precursor
Gene Name Name: GCAT
Synonyms:KBL;
Organism Homo sapiens (Human)

PRO ID PR:O75600
DAG View
PRO Name 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial (human)
Definition A 2-amino-3-ketobutyrate coenzyme A ligase that is encoded in the genome of human.
Short Label hGCAT
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75600 (GCAT) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K113 Ubiquitination PhosphoSitePlus
K118 Ubiquitination PhosphoSitePlus
K187 Ubiquitination PhosphoSitePlus
Y274 Phosphorylation PhosphoSitePlus
Y292 Phosphorylation PhosphoSitePlus
S307 Phosphorylation PhosphoSitePlus
K333 Ubiquitination PhosphoSitePlus
K368 Acetylation PhosphoSitePlus
S397 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K113 N113 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y274 C274 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
Y292 H292 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S397 R397 Biomuta DOID:1324 / lung cancer [ cosmic ]