iPTMnet Report for O75592 (MYCBP2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O75592 / MYCB2_HUMAN
Protein Name E3 ubiquitin-protein ligase MYCBP2
Gene Name Name: MYCBP2
Synonyms:KIAA0916;
Organism Homo sapiens (Human)

PRO ID PR:O75592
DAG View
PRO Name E3 ubiquitin-protein ligase MYCBP2 (human)
Definition An E3 ubiquitin-protein ligase MYCBP2 that is encoded in the genome of human.
Short Label hMYCBP2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75592 (MYCBP2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S69 Phosphorylation PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
S127 Phosphorylation PhosphoSitePlus   UniProt 23186163
S143 Phosphorylation phospho.ELM 18669648
S167 Phosphorylation PhosphoSitePlus
S175 Phosphorylation PhosphoSitePlus
S178 Phosphorylation PhosphoSitePlus   UniProt 18669648
S181 Phosphorylation PhosphoSitePlus   UniProt 18669648
S183 Phosphorylation PhosphoSitePlus   UniProt 18669648
T295 Phosphorylation PhosphoSitePlus
S300 Phosphorylation PhosphoSitePlus
R405 Methylation PhosphoSitePlus
S414 Phosphorylation PhosphoSitePlus
Y422 Phosphorylation PhosphoSitePlus
T434 Phosphorylation PhosphoSitePlus
K562 Ubiquitination PhosphoSitePlus
K578 Ubiquitination PhosphoSitePlus
T606 Phosphorylation PhosphoSitePlus
S608 Phosphorylation PhosphoSitePlus
S610 Phosphorylation PhosphoSitePlus
S617 Phosphorylation PhosphoSitePlus
T618 Phosphorylation PhosphoSitePlus
S620 Phosphorylation PhosphoSitePlus
K760 Ubiquitination PhosphoSitePlus
S924 Phosphorylation PhosphoSitePlus
K1046 Ubiquitination PhosphoSitePlus
S1161 Phosphorylation PhosphoSitePlus
Y1276 Phosphorylation PhosphoSitePlus
Y1315 Phosphorylation PhosphoSitePlus
Y1331 Phosphorylation PhosphoSitePlus
S1368 Phosphorylation PhosphoSitePlus
T1372 Phosphorylation PhosphoSitePlus
K1395 Ubiquitination PhosphoSitePlus
T1433 Phosphorylation PhosphoSitePlus
S1481 Phosphorylation PhosphoSitePlus
T1483 Phosphorylation PhosphoSitePlus
S1510 Phosphorylation PhosphoSitePlus
S1624 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1710 Phosphorylation PhosphoSitePlus
K1819 Ubiquitination PhosphoSitePlus
K1824 Ubiquitination PhosphoSitePlus
K1828 Acetylation PhosphoSitePlus
Y1829 Phosphorylation PhosphoSitePlus
K1898 Ubiquitination PhosphoSitePlus
S1914 O-Glycosylation GlyGen 30379171, 29351928
S1914 Phosphorylation PhosphoSitePlus
T1915 Phosphorylation PhosphoSitePlus
C2044 Methylation IEDB 31844290
K2132 Ubiquitination PhosphoSitePlus
K2175 Ubiquitination PhosphoSitePlus
C2246 Methylation IEDB 31844290
K2276 Ubiquitination PhosphoSitePlus
K2309 Ubiquitination PhosphoSitePlus
S2319 Phosphorylation PhosphoSitePlus
S2334 Phosphorylation PhosphoSitePlus
T2338 Phosphorylation PhosphoSitePlus
S2342 Phosphorylation PhosphoSitePlus
T2344 Phosphorylation PhosphoSitePlus
Y2348 Phosphorylation PhosphoSitePlus
S2353 Phosphorylation PhosphoSitePlus
S2359 Phosphorylation PhosphoSitePlus
K2443 Acetylation PhosphoSitePlus
K2447 Acetylation PhosphoSitePlus
K2458 Acetylation PhosphoSitePlus
K2460 Acetylation PhosphoSitePlus
S2555 Phosphorylation PhosphoSitePlus
K2556 Ubiquitination PhosphoSitePlus
S2643 Phosphorylation phospho.ELM 18669648, 17081983
T2683 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 19690332, ...20068231
S2687 Phosphorylation PhosphoSitePlus
S2690 Phosphorylation PhosphoSitePlus
S2699 Phosphorylation PhosphoSitePlus
S2701 Phosphorylation PhosphoSitePlus
S2712 Phosphorylation PhosphoSitePlus
S2720 Phosphorylation PhosphoSitePlus
T2728 Phosphorylation PhosphoSitePlus
S2732 Phosphorylation PhosphoSitePlus
S2736 Phosphorylation PhosphoSitePlus
S2749 Phosphorylation phospho.ELM 18669648, 17081983
S2769 Phosphorylation PhosphoSitePlus   UniProt 23186163
S2774 Phosphorylation phospho.ELM 15302935
S2787 Phosphorylation PhosphoSitePlus   UniProt 23186163
S2789 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163
T2794 Phosphorylation PhosphoSitePlus
S2808 Phosphorylation PhosphoSitePlus
S2812 Phosphorylation PhosphoSitePlus
S2817 Phosphorylation PhosphoSitePlus
S2821 Phosphorylation PhosphoSitePlus
K2823 Acetylation PhosphoSitePlus
K2825 Acetylation PhosphoSitePlus
T2826 Phosphorylation PhosphoSitePlus
S2833 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S2835 Phosphorylation PhosphoSitePlus
S2839 Phosphorylation PhosphoSitePlus   UniProt 23186163
S2843 Phosphorylation PhosphoSitePlus
S2844 Phosphorylation PhosphoSitePlus
K2848 Acetylation PhosphoSitePlus
T2860 Phosphorylation PhosphoSitePlus
S2869 Phosphorylation PhosphoSitePlus
S2871 Phosphorylation PhosphoSitePlus   UniProt 23186163
S2873 Phosphorylation PhosphoSitePlus
Y2874 Phosphorylation PhosphoSitePlus
T2875 Phosphorylation PhosphoSitePlus
T2880 Phosphorylation PhosphoSitePlus
S2896 Phosphorylation PhosphoSitePlus
T2897 Phosphorylation PhosphoSitePlus
S2903 Phosphorylation PhosphoSitePlus
S2920 Phosphorylation PhosphoSitePlus   UniProt 19690332
S2945 Phosphorylation PhosphoSitePlus
S2970 Phosphorylation PhosphoSitePlus
S2985 Phosphorylation PhosphoSitePlus   UniProt 23186163
K3003 Ubiquitination PhosphoSitePlus
K3009 Ubiquitination PhosphoSitePlus
K3063 Ubiquitination PhosphoSitePlus
T3078 Phosphorylation PhosphoSitePlus
K3081 Ubiquitination PhosphoSitePlus
S3090 Phosphorylation PhosphoSitePlus   UniProt 17081983
S3122 Phosphorylation PhosphoSitePlus
S3186 Phosphorylation PhosphoSitePlus
S3189 Phosphorylation PhosphoSitePlus
K3214 Methylation PhosphoSitePlus
Y3266 Phosphorylation PhosphoSitePlus
Y3272 Phosphorylation PhosphoSitePlus
S3274 Phosphorylation PhosphoSitePlus
S3294 Phosphorylation PhosphoSitePlus
S3377 Phosphorylation PhosphoSitePlus
Y3394 Phosphorylation PhosphoSitePlus
R3420 Methylation PhosphoSitePlus
Y3421 Phosphorylation PhosphoSitePlus
S3424 Phosphorylation PhosphoSitePlus
S3426 Phosphorylation PhosphoSitePlus
S3456 Phosphorylation PhosphoSitePlus
T3459 Phosphorylation PhosphoSitePlus
S3460 Phosphorylation PhosphoSitePlus
S3476 Phosphorylation PhosphoSitePlus
S3478 Phosphorylation PhosphoSitePlus   UniProt 18669648, 24275569
S3505 Phosphorylation PhosphoSitePlus   UniProt 18691976, 23186163, 19369195, ...18669648, 19690332, 20068231
T3508 Phosphorylation PhosphoSitePlus
S3519 Phosphorylation PhosphoSitePlus
S3523 Phosphorylation PhosphoSitePlus
S3527 Phosphorylation PhosphoSitePlus
K3534 Ubiquitination PhosphoSitePlus
K3749 Ubiquitination PhosphoSitePlus
K3788 Ubiquitination PhosphoSitePlus
Y3794 Phosphorylation PhosphoSitePlus
S3796 Phosphorylation PhosphoSitePlus
S3811 Phosphorylation PhosphoSitePlus
T3813 Phosphorylation PhosphoSitePlus
K3827 Ubiquitination PhosphoSitePlus
K3873 Ubiquitination PhosphoSitePlus
C3894 Methylation IEDB 31844290
T3921 Phosphorylation PhosphoSitePlus
K3927 Ubiquitination PhosphoSitePlus
S3931 Phosphorylation PhosphoSitePlus   UniProt 23186163
S3932 Phosphorylation PhosphoSitePlus   UniProt 23186163
K3938 Ubiquitination PhosphoSitePlus
T4070 Phosphorylation PhosphoSitePlus
T4118 O-Glycosylation GlyGen 29351928
K4124 Ubiquitination PhosphoSitePlus
T4126 Phosphorylation PhosphoSitePlus
T4131 Phosphorylation PhosphoSitePlus
T4135 Phosphorylation PhosphoSitePlus
T4141 Phosphorylation PhosphoSitePlus
S4151 Phosphorylation PhosphoSitePlus
S4152 Phosphorylation PhosphoSitePlus
Y4153 Phosphorylation PhosphoSitePlus
T4195 Phosphorylation PhosphoSitePlus
T4207 Phosphorylation PhosphoSitePlus
S4215 Phosphorylation PhosphoSitePlus
K4304 Ubiquitination PhosphoSitePlus
T4321 Phosphorylation PhosphoSitePlus
S4332 Phosphorylation PhosphoSitePlus
T4334 Phosphorylation PhosphoSitePlus
K4336 Acetylation PhosphoSitePlus
K4347 Acetylation PhosphoSitePlus
K4347 Ubiquitination PhosphoSitePlus
S4372 Phosphorylation PhosphoSitePlus
Y4382 Phosphorylation PhosphoSitePlus
Y4511 Phosphorylation PhosphoSitePlus
T4522 Phosphorylation PhosphoSitePlus
K4589 Ubiquitination PhosphoSitePlus
K4598 Ubiquitination PhosphoSitePlus
K4645 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S143 L143 Biomuta DOID:4159 / skin cancer [ cosmic ]
S143 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S2353 L2353 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S2643 F2643 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic ]
S2873 F2873 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K3081 N3081 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]