iPTMnet Report for O75586 (MED6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O75586 / MED6_HUMAN
Protein Name Mediator of RNA polymerase II transcription subunit 6
Gene Name Name: MED6
Synonyms:ARC33;
Organism Homo sapiens (Human)

PRO ID PR:O75586
DAG View
PRO Name mediator of RNA polymerase II transcription subunit 6 (human)
Definition A mediator of RNA polymerase II transcription subunit 6 that is encoded in the genome of human.
Short Label hMED6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75586 (MED6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K51 Ubiquitination PhosphoSitePlus
Y136 Phosphorylation PhosphoSitePlus
Y139 Phosphorylation PhosphoSitePlus
K143 Ubiquitination PhosphoSitePlus
Y145 Phosphorylation PhosphoSitePlus
K157 Ubiquitination PhosphoSitePlus
K165 Ubiquitination PhosphoSitePlus
K196 Ubiquitination PhosphoSitePlus
K200 Ubiquitination PhosphoSitePlus
K219 Sumoylation PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus
S234 Phosphorylation PhosphoSitePlus
K236 Acetylation PhosphoSitePlus   UniProt 19608861
K236 Ubiquitination PhosphoSitePlus
K241 Acetylation PhosphoSitePlus   UniProt 19608861


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K236 R236 Biomuta DOID:5041 / esophageal cancer [ cosmic ]