Protein Information

Cytoscape View


UniProt AC / UniProt ID O75581 / LRP6_HUMAN
Protein Name Low-density lipoprotein receptor-related protein 6 precursor
Gene Name Name: LRP6
Organism Homo sapiens (Human)

PRO ID PR:O75581
DAG View
PRO Name low-density lipoprotein receptor-related protein 6 (human)
Definition A low-density lipoprotein receptor-related protein 6 that is encoded in the genome of human.
Short Label hLRP6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75581 (LRP6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K108 Ubiquitination PhosphoSitePlus
S122 Phosphorylation HPRD 20230923
S127 Phosphorylation HPRD 20230923
S171 Phosphorylation PhosphoSitePlus
S172 Phosphorylation PhosphoSitePlus
S209 Phosphorylation PhosphoSitePlus
T214 Phosphorylation PhosphoSitePlus
Y375 Phosphorylation RLIMS-P 22558232
N692 N-Glycosylation UniProt 22000856
K733 Ubiquitination PhosphoSitePlus
K802 Acetylation PhosphoSitePlus
N859 N-Glycosylation UniProt 22000856
N865 N-Glycosylation UniProt 22000856
N926 N-Glycosylation UniProt 22000856
K941 Ubiquitination PhosphoSitePlus
K977 Ubiquitination PhosphoSitePlus
T1001 Phosphorylation PhosphoSitePlus
N1039 N-Glycosylation UniProt 22000856
K1195 Ubiquitination PhosphoSitePlus
K1403 Ubiquitination UniProt 18378904
S1420 Phosphorylation P49674 (CSNK1E) PhosphoSitePlus   Signor   UniProt 16513652
S1430 Phosphorylation P49674 (CSNK1E) Signor   UniProt 16513652
S1431 Phosphorylation P49674 (CSNK1E) PhosphoSitePlus 16513652
K1443 Ubiquitination PhosphoSitePlus
S1444 Phosphorylation PhosphoSitePlus
S1448 Phosphorylation P34947 (GRK5) , P43250 (GRK6) neXtProt 19801552
S1450 Phosphorylation P34947 (GRK5) neXtProt 19801552
S1455 Phosphorylation PhosphoSitePlus
Y1460 Phosphorylation PhosphoSitePlus
S1474 Phosphorylation PhosphoSitePlus
S1475 Phosphorylation PhosphoSitePlus
T1476 Phosphorylation PhosphoSitePlus
T1479 Phosphorylation Q9HCP0 (CSNK1G1) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 16341016, 22246988, 18772438, ...17569865, 18762581, 21606194
Y1480 Phosphorylation PhosphoSitePlus
S1490 Phosphorylation P28482 (MAPK1) , P34947 (GRK5) , P49841 (GSK3B) , P27361 (MAPK3) , O94921 (CDK14) , P43250 (GRK6) HPRD   neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 29444668, 20059949, 18762581, ...23400998, 27203244, 22357953, 23186163, 17698587, 30664649, 23638027, 16365045, 22558232, 28674183, 27821587, 19801552, 24265322, 16341017, 16890161, 27530555, 25331957, 21935433, 22246988, 18772438, 30109182, 25500543
T1493 Phosphorylation P48729 (CSNK1A1) PhosphoSitePlus   RLIMS-P   Signor   UniProt 22246988, 18762581, 16341017
S1496 Phosphorylation PhosphoSitePlus
Y1498 Phosphorylation PhosphoSitePlus
T1499 Phosphorylation PhosphoSitePlus
Y1504 Phosphorylation PhosphoSitePlus
S1506 Phosphorylation PhosphoSitePlus
S1508 Phosphorylation P34947 (GRK5) , P43250 (GRK6) neXtProt   PhosphoSitePlus 19801552
S1510 Phosphorylation PhosphoSitePlus
Y1515 Phosphorylation PhosphoSitePlus
S1516 Phosphorylation PhosphoSitePlus
Y1517 Phosphorylation PhosphoSitePlus
R1518 Methylation PhosphoSitePlus
Y1520 Phosphorylation PhosphoSitePlus
S1521 Phosphorylation PhosphoSitePlus
Y1522 Phosphorylation PhosphoSitePlus
Y1541 Phosphorylation PhosphoSitePlus
S1544 Phosphorylation P49840 (GSK3A) PhosphoSitePlus 21406690
T1548 Phosphorylation P17612 (PRKACA) neXtProt   PhosphoSitePlus 21406690
K1554 Ubiquitination PhosphoSitePlus
Y1562 Phosphorylation PhosphoSitePlus
T1572 Phosphorylation P49841 (GSK3B) , P34947 (GRK5) , P43250 (GRK6) , P27361 (MAPK3) , P28482 (MAPK1) HPRD   neXtProt   PhosphoSitePlus   RLIMS-P 16365045, 19801552, 25500543, ...22558232
S1575 Phosphorylation PhosphoSitePlus
Y1577 Phosphorylation PhosphoSitePlus
S1579 Phosphorylation PhosphoSitePlus
Y1584 Phosphorylation PhosphoSitePlus
S1590 Phosphorylation P34947 (GRK5) , P43250 (GRK6) neXtProt   PhosphoSitePlus 19801552
S1607 Phosphorylation P49841 (GSK3B) , P34947 (GRK5) HPRD   neXtProt   PhosphoSitePlus 16365045, 19801552
S1612 Phosphorylation PhosphoSitePlus
S1613 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S127 T127 Biomuta DOID:3571 / liver cancer [ icgc ]
S209 * Biomuta DOID:1324 / lung cancer [ tcga ]
T1001 N1001 Biomuta DOID:3571 / liver cancer [ icgc ]
S1431 F1431 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S1431 Y1431 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
S1455 R1455 Biomuta DOID:3571 / liver cancer [ icgc ]
S1508 R1508 Biomuta DOID:9256 / colorectal cancer [ tcga ]
Y1520 C1520 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
Y1541 S1541 Biomuta DOID:1324 / lung cancer [ tcga ]
T1548 N1548 Biomuta DOID:3571 / liver cancer [ icgc ]
T1572 K1572 Biomuta DOID:3571 / liver cancer [ icgc ]
S1579 P1579 Biomuta DOID:1324 / lung cancer [ tcga ]
S1613 Y1613 Biomuta DOID:2394 / ovarian cancer [ icgc, tcga ] DOID:2994 / germ cell cancer [ cosmic ]
S1613 F1613 Biomuta DOID:3070 / malignant glioma [ cosmic, icgc ]