iPTMnet Report for O75570 (MTRF1)
Protein Information
| UniProt AC / UniProt ID | O75570 / RF1M_HUMAN |
| Protein Name | Peptide chain release factor 1, mitochondrial precursor |
| Gene Name | Name: MTRF1 |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:O75570 |
| PRO Name | peptide chain release factor 1, mitochondrial (human) |
| Definition | A peptide chain release factor 1, mitochondrial that is encoded in the genome of human. |
| Short Label | hMTRF1 |
| Category | organism-gene |
DAG ViewO75570 (MTRF1) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| K77 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y120 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S139 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K146 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T190 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y227 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y248 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y253 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T304 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Q313 | Methylation | score2 | UniProt | 35260756 | ||
| S427 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K442 | Ubiquitination | score1 | PhosphoSitePlus |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| Y120 | H120 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| Y120 | C120 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| Y120 | * | Biomuta | DOID:4362 / cervical cancer [ cosmic ] | |
| T304 | A304 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| S427 | L427 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] |
