iPTMnet Report for O75569 (PRKRA)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O75569 / PRKRA_HUMAN
Protein Name Interferon-inducible double-stranded RNA-dependent protein kinase activator A
Gene Name Name: PRKRA
Synonyms:PACT,RAX;ORFNames:HSD-14,HSD14;
Organism Homo sapiens (Human)

PRO ID PR:O75569
DAG View
PRO Name interferon-inducible double-stranded RNA-dependent protein kinase activator A (human)
Definition An interferon-inducible double-stranded RNA-dependent protein kinase activator A that is encoded in the genome of human.
Short Label hPRKRA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75569 (PRKRA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S18 Phosphorylation IEDB   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17287340, 17081983, ...27920218, 18669648, 23186163, 20068231
T20 Phosphorylation IEDB   phospho.ELM   PhosphoSitePlus 27920218, 18669648
S22 Phosphorylation PhosphoSitePlus
K30 Ubiquitination PhosphoSitePlus
K45 Ubiquitination PhosphoSitePlus
K47 Ubiquitination PhosphoSitePlus
T67 Phosphorylation PhosphoSitePlus
T71 Phosphorylation PhosphoSitePlus
S130 Phosphorylation PhosphoSitePlus
K156 Ubiquitination PhosphoSitePlus
Y159 Phosphorylation PhosphoSitePlus
T160 Phosphorylation PhosphoSitePlus
C163 Methylation IEDB 31844290
S167 Phosphorylation PhosphoSitePlus   UniProt 23186163
K187 Ubiquitination PhosphoSitePlus
S196 Phosphorylation PhosphoSitePlus
S202 Phosphorylation PhosphoSitePlus
S217 Phosphorylation PhosphoSitePlus
K225 Ubiquitination PhosphoSitePlus
S232 Phosphorylation PhosphoSitePlus
S235 Phosphorylation PhosphoSitePlus
Y241 Phosphorylation PhosphoSitePlus
S246 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 22473766, 16982605
Y270 Phosphorylation PhosphoSitePlus
C284 Methylation IEDB 31844290
S287 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 22473766, 21526770, 16982605
Site PTM Type PTM Enzyme Score Source PMID
S18 Phosphorylation HPRD 17287340, 17081983, 20230923, ...18767875, 19651622, 18669648, 20166139, 20068231, 18212344
T20 Phosphorylation HPRD 19651622, 18767875, 18669648, ...20068231, 20230923
S22 Phosphorylation HPRD 19651622, 20230923
T34 Phosphorylation HPRD 20068231
T71 Phosphorylation HPRD 20068231
T78 Phosphorylation HPRD 20068231


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O75569 (PRKRA) S287 P19525 (EIF2AK2) increased_association eFIP 23658827


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T34 K34 Biomuta DOID:1612 / breast cancer [ icgc ]
S196 F196 Biomuta DOID:1319 / brain cancer [ icgc ]
K225 N225 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S235 I235 Biomuta DOID:1793 / pancreatic cancer [ cosmic, icgc ]
S235 T235 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
Y270 * Biomuta DOID:4159 / skin cancer [ cosmic ]
Y270 F270 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S287 F287 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]