iPTMnet Report for O75563 (SKAP2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O75563 / SKAP2_HUMAN
Protein Name Src kinase-associated phosphoprotein 2
Gene Name Name: SKAP2
Synonyms:PRAP,RA70,SAPS,SCAP2,SKAP55R;
Organism Homo sapiens (Human)

PRO ID PR:O75563
DAG View
PRO Name Src kinase-associated phosphoprotein 2 (human)
Definition A Src kinase-associated phosphoprotein 2 that is encoded in the genome of human.
Short Label hSKAP2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75563 (SKAP2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S5 Phosphorylation PhosphoSitePlus   UniProt 23186163
S6 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
T7 Phosphorylation PhosphoSitePlus
S9 Phosphorylation PhosphoSitePlus
Y11 Phosphorylation PhosphoSitePlus
S47 Phosphorylation PhosphoSitePlus
K56 Ubiquitination PhosphoSitePlus
K66 Ubiquitination PhosphoSitePlus
Y75 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 29568343, 21719704
T85 Phosphorylation PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
Y122 Phosphorylation PhosphoSitePlus
K125 Ubiquitination PhosphoSitePlus
T147 Phosphorylation PhosphoSitePlus
Y151 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
Y152 Phosphorylation PhosphoSitePlus
S154 Phosphorylation PhosphoSitePlus
K194 Ubiquitination PhosphoSitePlus
Y197 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 15592455, 18083107, 24275569
S203 Phosphorylation PhosphoSitePlus
K205 Ubiquitination PhosphoSitePlus
Y237 Phosphorylation PhosphoSitePlus   RLIMS-P 29568343
S253 Phosphorylation PhosphoSitePlus
Y261 Phosphorylation PhosphoSitePlus   RLIMS-P 29568343
K281 Ubiquitination PhosphoSitePlus
S283 Phosphorylation PhosphoSitePlus
S286 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
T290 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
Y325 Phosphorylation HPRD   PhosphoSitePlus 17081983
S328 Phosphorylation PhosphoSitePlus
K329 Ubiquitination PhosphoSitePlus
Y331 Phosphorylation PhosphoSitePlus
Y334 Phosphorylation PhosphoSitePlus
K350 Ubiquitination PhosphoSitePlus
Y357 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S5 N5 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S9 T9 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
Y11 F11 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S47 F47 Biomuta DOID:4159 / skin cancer [ cosmic ]
S203 F203 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
Y261 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S286 N286 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
Y331 C331 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
K350 E350 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]