Protein Information

Cytoscape View


UniProt AC / UniProt ID O75553 / DAB1_HUMAN
Protein Name Disabled homolog 1
Gene Name Name: DAB1
Organism Homo sapiens (Human)

PRO ID PR:O75553
DAG View
PRO Name disabled homolog 1 (human)
Definition A disabled homolog 1 that is encoded in the genome of human.
Short Label hDAB1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75553 (DAB1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K43 Ubiquitination PhosphoSitePlus
K45 Ubiquitination PhosphoSitePlus
K84 Sumoylation PhosphoSitePlus
Y198 Phosphorylation phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P 27602387, 15316068, 18593473
Y220 Phosphorylation phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P 15316068, 19116273
Y232 Phosphorylation phospho.ELM   PRO   PhosphoSitePlus 15316068
S433 Phosphorylation neXtProt 12077184, 18076569
T506 Phosphorylation PhosphoSitePlus
S524 Phosphorylation P24941 (CDK2) neXtProt   phospho.ELM   PhosphoSitePlus 12077184, 18076569, 21111810
S526 Phosphorylation PhosphoSitePlus
S548 Phosphorylation phospho.ELM 12077184
Site PTM Type PTM Enzyme Score Source PMID
Y185 Phosphorylation P12931 (SRC) HPRD 10959835, 11279201
Y198 Phosphorylation P12931 (SRC) HPRD 10959835, 11279201
Y200 Phosphorylation P12931 (SRC) HPRD 10959835, 11279201
Y220 Phosphorylation P12931 (SRC) HPRD 10959835, 11279201
Y232 Phosphorylation P12931 (SRC) HPRD 10959835, 11279201
S491 Phosphorylation Q00535 (CDK5) HPRD 12077184
S515 Phosphorylation Q00535 (CDK5) HPRD 12077184


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047132 (hDAB1/Phos:1) pY198,pY220,pY232 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K84 N84 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
Y198 * Biomuta DOID:3571 / liver cancer [ icgc ]
Y220 H220 Biomuta DOID:1793 / pancreatic cancer [ icgc, tcga ] DOID:10283 / prostate cancer [ cosmic ]
Y232 H232 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S433 N433 Biomuta DOID:1793 / pancreatic cancer [ icgc, tcga ] DOID:10283 / prostate cancer [ cosmic ]
S526 F526 Biomuta DOID:1909 / melanoma [ icgc, tcga ] DOID:1324 / lung cancer [ cosmic ]
S548 N548 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S548 R548 Biomuta DOID:5041 / esophageal cancer [ icgc ]