Protein Information

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UniProt AC / UniProt ID O75533 / SF3B1_HUMAN
Protein Name Splicing factor 3B subunit 1
Gene Name Name: SF3B1
Synonyms:SAP155;
Organism Homo sapiens (Human)

PRO ID PR:O75533
DAG View
PRO Name splicing factor 3B subunit 1 (human)
Definition A splicing factor 3B subunit 1 that is encoded in the genome of human.
Short Label hSF3B1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75533 (SF3B1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K6 Ubiquitination PhosphoSitePlus
K21 Ubiquitination PhosphoSitePlus
K22 Ubiquitination PhosphoSitePlus
T36 Phosphorylation PhosphoSitePlus
Y38 Phosphorylation PhosphoSitePlus
Y39 Phosphorylation PhosphoSitePlus
Y44 Phosphorylation PhosphoSitePlus
T61 Phosphorylation PhosphoSitePlus
Y70 Phosphorylation PhosphoSitePlus
S72 Phosphorylation PhosphoSitePlus
S73 Phosphorylation PhosphoSitePlus
S75 Phosphorylation PhosphoSitePlus
K81 Ubiquitination PhosphoSitePlus
Y84 Phosphorylation PhosphoSitePlus
Y101 Phosphorylation PhosphoSitePlus
Y119 Phosphorylation PhosphoSitePlus
K120 Acetylation PhosphoSitePlus
T125 Phosphorylation PhosphoSitePlus   UniProt 23186163
S129 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 24275569, 20068231
K141 Acetylation PhosphoSitePlus   UniProt 19608861
K141 Ubiquitination PhosphoSitePlus
T142 Phosphorylation P24941 (CDK2) PhosphoSitePlus   UniProt 18669648, 23186163, 18847512, ...17924679
K146 Ubiquitination PhosphoSitePlus
Y152 Phosphorylation PhosphoSitePlus
K175 Ubiquitination PhosphoSitePlus
K177 Methylation PhosphoSitePlus
K182 Ubiquitination PhosphoSitePlus
S190 Phosphorylation PhosphoSitePlus
S194 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
K195 Acetylation PhosphoSitePlus
K195 Methylation PhosphoSitePlus
K195 Ubiquitination PhosphoSitePlus
T203 Phosphorylation PhosphoSitePlus   UniProt 20068231
T207 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16964243, 18220336, ...18669648, 19690332, 20068231, 17081983
T211 Phosphorylation P24941 (CDK2) phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 16964243, ...18847512, 18669648, 24275569, 19690332, 20068231, 17081983
K213 Ubiquitination PhosphoSitePlus
K214 Acetylation PhosphoSitePlus
K214 Sumoylation PhosphoSitePlus
K214 Ubiquitination PhosphoSitePlus
S216 Phosphorylation PhosphoSitePlus
S217 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
T223 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18220336, ...18669648, 19690332, 20068231, 17924679
T227 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18220336, ...18669648, 19690332
S229 Phosphorylation PhosphoSitePlus
R231 Methylation PhosphoSitePlus
T235 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 16083285, 23186163
K240 Methylation PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
S242 Phosphorylation PhosphoSitePlus
T244 Phosphorylation P24941 (CDK2) phospho.ELM   PhosphoSitePlus   Signor   UniProt 12105215, 17081983
T248 Phosphorylation P24941 (CDK2) phospho.ELM   PhosphoSitePlus   Signor   UniProt 12105215, 17081983
S251 Phosphorylation PhosphoSitePlus
T257 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 24275569, 18220336
S259 Phosphorylation P24941 (CDK2) phospho.ELM   PhosphoSitePlus 18669648, 18847512
T261 Phosphorylation P24941 (CDK2) phospho.ELM   PhosphoSitePlus   UniProt 18847512, 23186163, 24275569, ...18220336
T267 Phosphorylation P24941 (CDK2) phospho.ELM   PhosphoSitePlus   UniProt 18847512, 23186163, 24275569, ...18220336
T273 Phosphorylation Q13627 (DYRK1A) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18669648, 16512921, 24275569
T278 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
T285 Phosphorylation PhosphoSitePlus
S286 Phosphorylation PhosphoSitePlus
S287 Phosphorylation PhosphoSitePlus   UniProt 24275569
T296 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983
T299 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983, 18220336
T303 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 24275569
S308 Phosphorylation PhosphoSitePlus
T313 Phosphorylation P24941 (CDK2) phospho.ELM   PhosphoSitePlus   Signor   UniProt 12105215, 23186163, 24275569, ...18220336
T316 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
R318 Methylation PhosphoSitePlus
S322 Phosphorylation PhosphoSitePlus   UniProt 23186163
T326 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16964243, 18669648, ...19690332, 20068231, 17081983
T328 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 16964243, 20068231
S332 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
K333 Acetylation PhosphoSitePlus
K333 Ubiquitination PhosphoSitePlus
T341 Phosphorylation PhosphoSitePlus   UniProt 21406692, 19690332
S344 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983
S349 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 19690332
T350 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15302935, 23186163, 19690332
T354 Phosphorylation P24941 (CDK2) phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...18847512, 15302935
T362 Phosphorylation PhosphoSitePlus
T369 Phosphorylation PhosphoSitePlus
T371 Phosphorylation PhosphoSitePlus
S377 Phosphorylation PhosphoSitePlus
T379 Phosphorylation PhosphoSitePlus
S400 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332
K413 Sumoylation PhosphoSitePlus
K413 Ubiquitination PhosphoSitePlus
Y421 Phosphorylation PhosphoSitePlus
T426 Phosphorylation P24941 (CDK2) PhosphoSitePlus   UniProt 18847512, 23186163
K430 Acetylation PhosphoSitePlus
T432 Phosphorylation P24941 (CDK2) phospho.ELM   PhosphoSitePlus 18847512, 18220336
T434 Phosphorylation Q9Y463 (DYRK1B) , Q13627 (DYRK1A) , P24941 (CDK2) IntAct   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 23186163, 17081983, 26192590, ...19796173, 23809146, 18847512, 16512921, 21553260, 19690332
T436 Phosphorylation P24941 (CDK2) phospho.ELM   PhosphoSitePlus   UniProt 18847512, 23186163, 19690332, ...17081983
T442 Phosphorylation PhosphoSitePlus
K454 Ubiquitination PhosphoSitePlus
K468 Sumoylation PhosphoSitePlus
K468 Ubiquitination PhosphoSitePlus
Y474 Phosphorylation PhosphoSitePlus
K477 Ubiquitination PhosphoSitePlus
S488 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231, ...24275569
K493 Ubiquitination PhosphoSitePlus
K499 Sumoylation PhosphoSitePlus
K499 Ubiquitination PhosphoSitePlus
T508 Phosphorylation PhosphoSitePlus
R517 Methylation PhosphoSitePlus
S541 Phosphorylation PhosphoSitePlus
K554 Acetylation PhosphoSitePlus   UniProt 19608861
K554 Ubiquitination PhosphoSitePlus
R558 Methylation PhosphoSitePlus
K562 Acetylation PhosphoSitePlus   UniProt 19608861
K700 Ubiquitination PhosphoSitePlus
K733 Ubiquitination PhosphoSitePlus
Y761 Phosphorylation PhosphoSitePlus
Y764 Phosphorylation PhosphoSitePlus
K785 Ubiquitination PhosphoSitePlus
K790 Ubiquitination PhosphoSitePlus
K793 Ubiquitination PhosphoSitePlus
T808 Phosphorylation PhosphoSitePlus
K816 Ubiquitination PhosphoSitePlus
S851 Phosphorylation PhosphoSitePlus
K858 Ubiquitination PhosphoSitePlus
K866 Ubiquitination PhosphoSitePlus
K874 Ubiquitination PhosphoSitePlus
K926 Ubiquitination PhosphoSitePlus
K963 Ubiquitination PhosphoSitePlus
K1008 Ubiquitination PhosphoSitePlus
K1014 Ubiquitination PhosphoSitePlus
T1021 Phosphorylation PhosphoSitePlus
K1025 Ubiquitination PhosphoSitePlus
K1030 Ubiquitination PhosphoSitePlus
R1045 Methylation PhosphoSitePlus
C1059 S-Nitrosylation dbSNO 22178444
K1067 Acetylation PhosphoSitePlus
K1102 Ubiquitination PhosphoSitePlus
Y1136 Phosphorylation PhosphoSitePlus
T1170 Phosphorylation PhosphoSitePlus
R1180 Methylation PhosphoSitePlus
Y1288 Phosphorylation PhosphoSitePlus
K1292 Ubiquitination PhosphoSitePlus
Y1295 Phosphorylation PhosphoSitePlus
Y1302 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T125 Phosphorylation HPRD 19651622, 17081983, 20068231
S129 Phosphorylation HPRD 19651622, 18669648, 19664994, ...17081983, 20068231
T142 Phosphorylation HPRD 19651622, 18669648, 18212344, ...20068231, 17924679
S190 Phosphorylation HPRD 20068231
S194 Phosphorylation HPRD 19413330, 18669648, 19664995, ...20068231
T203 Phosphorylation HPRD 17081983, 20068231
T207 Phosphorylation HPRD 19413330, 16964243, 19664995, ...18669648, 19415658, 20068231, 17081983
T211 Phosphorylation HPRD 19413330, 18691976, 16964243, ...19664995, 19651622, 18669648, 19415658, 20068231, 17081983
S216 Phosphorylation HPRD 17081983
S217 Phosphorylation HPRD 17081983, 20068231
T223 Phosphorylation HPRD 17081983, 18212344, 19664995, ...19651622, 18669648, 20068231, 17924679
T227 Phosphorylation HPRD 19651622, 18669648, 18212344, ...20068231, 19664995
S229 Phosphorylation HPRD 17081983, 20068231
T235 Phosphorylation HPRD 18669648, 20068231
T244 Phosphorylation HPRD 17081983, 20068231, 17924679
T248 Phosphorylation HPRD 17081983, 20068231
S251 Phosphorylation HPRD 20068230
S259 Phosphorylation HPRD 18669648
T261 Phosphorylation HPRD 19651622, 20068231
T267 Phosphorylation HPRD 19413330, 19651622
T273 Phosphorylation HPRD 19413330, 18669648, 20068231
T278 Phosphorylation HPRD 19664995
T296 Phosphorylation HPRD 17081983, 20068231
T299 Phosphorylation HPRD 17081983
T303 Phosphorylation HPRD 17081983, 20068231, 18707149
S308 Phosphorylation HPRD 17081983
T313 Phosphorylation HPRD 19651622, 17081983, 20068231, ...18212344
T316 Phosphorylation HPRD 17081983
S322 Phosphorylation HPRD 19413330
T326 Phosphorylation HPRD 19413330, 17081983, 16964243, ...19664995, 19651622, 18669648, 20068231, 20068230
T328 Phosphorylation HPRD 19413330, 16964243, 19664995, ...19651622, 18669648, 20068231
S332 Phosphorylation HPRD 18669648
S344 Phosphorylation HPRD 15302935
S349 Phosphorylation HPRD 19413330, 17081983, 19664995
T350 Phosphorylation HPRD 19413330, 15302935, 19664995, ...20068231
T354 Phosphorylation HPRD 19413330, 18691976, 15302935
T432 Phosphorylation HPRD 17081983, 20068231
T434 Phosphorylation Q13627 (DYRK1A) HPRD 16512921, 20068231
T442 Phosphorylation HPRD 20068231
S485 Phosphorylation HPRD 18691976, 17081983
S488 Phosphorylation HPRD 19413330, 18691976, 18452278, ...19651622, 18669648, 20068231
T608 Phosphorylation HPRD 20068231
S851 Phosphorylation HPRD 20068231
Y1136 Phosphorylation HPRD 20068230


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O75533 (SF3B1) T434 Q63470 (Dyrk1a) unknown eFIP 23809146


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S73 F73 Biomuta DOID:1324 / lung cancer [ icgc, tcga ]
Y101 C101 Biomuta DOID:11934 / head and neck cancer [ tcga ]
K120 R120 Biomuta DOID:363 / uterine cancer [ cosmic, tcga ]
K120 Q120 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
T125 N125 Biomuta DOID:3571 / liver cancer [ icgc ]
K177 N177 Biomuta DOID:1324 / lung cancer [ tcga ]
S229 F229 Biomuta DOID:1909 / melanoma [ tcga ]
R231 I231 Biomuta DOID:1324 / lung cancer [ tcga ]
T235 K235 Biomuta DOID:3571 / liver cancer [ icgc ]
S259 R259 Biomuta DOID:1324 / lung cancer [ cosmic ]
T267 N267 Biomuta DOID:263 / kidney cancer [ icgc, tcga ]
S286 C286 Biomuta DOID:11934 / head and neck cancer [ tcga ]
S308 R308 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
T316 A316 Biomuta DOID:3070 / malignant glioma [ tcga ]
T354 N354 Biomuta DOID:3571 / liver cancer [ icgc ]
S377 N377 Biomuta DOID:363 / uterine cancer [ tcga ]
S541 P541 Biomuta DOID:3070 / malignant glioma [ cosmic, icgc, tcga ]
S541 F541 Biomuta DOID:1612 / breast cancer [ cosmic ]
K700 E700 Biomuta DOID:1793 / pancreatic cancer [ tcga ] DOID:1612 / breast cancer [ civic, icgc, tcga ] DOID:1909 / melanoma [ tcga ] DOID:3277 / thymus cancer [ tcga ] DOID:1115 / sarcoma [ tcga ]
K700 R700 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
K700 T700 Biomuta DOID:2531 / hematologic cancer [ icgc ]
Y764 C764 Biomuta DOID:3571 / liver cancer [ tcga ]
K1025 N1025 Biomuta DOID:9256 / colorectal cancer [ icgc ]
R1045 W1045 Biomuta DOID:11934 / head and neck cancer [ tcga ]