iPTMnet Report for O75521 (ECI2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O75521 / ECI2_HUMAN
Protein Name Enoyl-CoA delta isomerase 2 precursor
Gene Name Name: ECI2
Synonyms:DRS1,HCA88,PECI;
Organism Homo sapiens (Human)

PRO ID PR:O75521
DAG View
PRO Name enoyl-CoA Delta isomerase 2 (human)
Definition An enoyl-CoA Delta isomerase 2 that is encoded in the genome of human.
Short Label hECI2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75521 (ECI2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S39 Phosphorylation PhosphoSitePlus
K41 Acetylation PhosphoSitePlus
K51 Acetylation PhosphoSitePlus   UniProt 19608861
K54 Acetylation PhosphoSitePlus
K62 Acetylation PhosphoSitePlus
Y66 Phosphorylation PhosphoSitePlus
K92 Acetylation PhosphoSitePlus   UniProt 19608861
K92 Ubiquitination PhosphoSitePlus
S101 Phosphorylation PhosphoSitePlus   UniProt 24275569
K104 Acetylation PhosphoSitePlus
S119 Phosphorylation PhosphoSitePlus   UniProt 23186163
S121 Phosphorylation PhosphoSitePlus
S125 Phosphorylation PhosphoSitePlus
K135 Ubiquitination PhosphoSitePlus
S136 Phosphorylation PhosphoSitePlus
T137 Phosphorylation PhosphoSitePlus
K152 Acetylation PhosphoSitePlus
K159 Acetylation PhosphoSitePlus
K160 Acetylation PhosphoSitePlus
T166 Phosphorylation PhosphoSitePlus
Y169 Phosphorylation PhosphoSitePlus
S278 Phosphorylation PhosphoSitePlus
S283 Phosphorylation PhosphoSitePlus
S284 Phosphorylation PhosphoSitePlus
Y285 Phosphorylation PhosphoSitePlus
T286 Phosphorylation PhosphoSitePlus
K289 Acetylation PhosphoSitePlus
K305 Acetylation PhosphoSitePlus
K349 Ubiquitination PhosphoSitePlus
K359 Acetylation PhosphoSitePlus
K393 Acetylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K41 N41 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K51 I51 Biomuta DOID:3571 / liver cancer [ cosmic ]
K104 R104 Biomuta DOID:5158 / pleural cancer [ cosmic ]
S121 L121 Biomuta DOID:4159 / skin cancer [ cosmic ]
S125 F125 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K152 E152 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
Y285 * Biomuta DOID:3571 / liver cancer [ cosmic ]
T286 P286 Biomuta DOID:2394 / ovarian cancer [ icgc ]
K359 N359 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic ]