iPTMnet Report for O75509 (TNFRSF21)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O75509 / TNR21_HUMAN
Protein Name Tumor necrosis factor receptor superfamily member 21 precursor
Gene Name Name: TNFRSF21
Synonyms:DR6;ORFNames:UNQ437/PRO868;
Organism Homo sapiens (Human)

PRO ID PR:O75509
DAG View
PRO Name tumor necrosis factor receptor superfamily member 21 (human)
Definition A tumor necrosis factor receptor superfamily member 21 that is encoded in the genome of human.
Short Label hTNFRSF21
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75509 (TNFRSF21) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S4 Phosphorylation PhosphoSitePlus
S13 Phosphorylation PhosphoSitePlus
T22 Phosphorylation PhosphoSitePlus
T24 Phosphorylation PhosphoSitePlus
N82 N-Glycosylation GlyGen   UniProt 23090970, 19654028, 29391424, ...24190977
N141 N-Glycosylation GlyGen   UniProt 23090970, 19654028, 24190977
S177 Phosphorylation PhosphoSitePlus
S181 Phosphorylation PhosphoSitePlus
S182 Phosphorylation PhosphoSitePlus
T227 O-Glycosylation GlyGen 30459171
N252 N-Glycosylation GlyGen   UniProt 19654028, 29391424
N257 N-Glycosylation GlyGen   UniProt 19654028
S258 O-Glycosylation GlyGen 25813380
S259 O-Glycosylation GlyGen 25813380
S261 O-Glycosylation GlyGen 25813380
N278 N-Glycosylation GlyGen   UniProt 23090970, 19654028, 29391424, ...24190977
N289 N-Glycosylation GlyGen   UniProt 19654028
S315 Phosphorylation PhosphoSitePlus
T319 Phosphorylation PhosphoSitePlus
T376 Phosphorylation PhosphoSitePlus
S386 Phosphorylation PhosphoSitePlus
Y409 Phosphorylation PhosphoSitePlus
Y410 Phosphorylation PhosphoSitePlus
Y434 Phosphorylation PhosphoSitePlus
N439 N-Glycosylation GlyGen 29391424
Y460 Phosphorylation PhosphoSitePlus
S525 Phosphorylation PhosphoSitePlus
S533 Phosphorylation PhosphoSitePlus
S541 Phosphorylation HPRD   PhosphoSitePlus 18578522
K545 Acetylation PhosphoSitePlus
K547 Acetylation PhosphoSitePlus
K547 Ubiquitination PhosphoSitePlus
S562 Phosphorylation PhosphoSitePlus
T563 Phosphorylation PhosphoSitePlus
S564 Phosphorylation PhosphoSitePlus
S565 Phosphorylation PhosphoSitePlus
S567 Phosphorylation PhosphoSitePlus
S568 Phosphorylation PhosphoSitePlus
S571 Phosphorylation PhosphoSitePlus
N573 N-Glycosylation GlyGen 29391424
S575 Phosphorylation PhosphoSitePlus
Y648 Phosphorylation PhosphoSitePlus
S649 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T24 M24 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
N141 D141 Biomuta DOID:1319 / brain cancer [ cosmic ]
S258 F258 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S261 F261 Biomuta DOID:4159 / skin cancer [ cosmic ]
T376 S376 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S533 F533 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K545 N545 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S564 F564 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S565 C565 Biomuta DOID:1324 / lung cancer [ cosmic ]
S568 F568 Biomuta DOID:4159 / skin cancer [ cosmic ]