iPTMnet Report for O75496 (GMNN)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O75496 / GEMI_HUMAN
Protein Name Geminin
Gene Name Name: GMNN
Organism Homo sapiens (Human)

PRO ID PR:O75496
DAG View
PRO Name geminin (human)
Definition A geminin that is encoded in the genome of human.
Short Label hGMNN
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75496 (GMNN) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K17 Ubiquitination PhosphoSitePlus
T25 Phosphorylation PhosphoSitePlus   RLIMS-P 23695679
T25 Phosphorylation O14965 (AURKA) PhosphoSitePlus 23695679
K27 Acetylation PhosphoSitePlus   UniProt 19608861
K27 Ubiquitination PhosphoSitePlus
S32 O-Glycosylation GlyGen 31373491
S32 Phosphorylation RLIMS-P 23695679
S34 O-Glycosylation GlyGen 31373491
S34 Phosphorylation PhosphoSitePlus   UniProt 23186163
S36 O-Glycosylation GlyGen 30379171, 31373491
S36 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20068231
S45 O-Glycosylation GlyGen 31373491
S45 Phosphorylation HPRD   PhosphoSitePlus 12745091, 20068231
S49 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 12745091, 20068231
K50 Acetylation PhosphoSitePlus
K50 Ubiquitination PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
T59 Phosphorylation HPRD   PhosphoSitePlus 20068231
S60 Phosphorylation HPRD   phospho.ELM   RLIMS-P 18669648, 23695679
T61 Phosphorylation PhosphoSitePlus
S63 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
S64 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18669648, 17287340, ...20068231
S72 Phosphorylation HPRD 20068231
K76 Ubiquitination PhosphoSitePlus
S85 Phosphorylation PhosphoSitePlus
K91 Ubiquitination PhosphoSitePlus
S95 Phosphorylation PhosphoSitePlus
S96 Phosphorylation PhosphoSitePlus
Y98 Phosphorylation PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
K105 Acetylation PhosphoSitePlus
K108 Ubiquitination PhosphoSitePlus
K115 Ubiquitination PhosphoSitePlus
K122 Ubiquitination PhosphoSitePlus
K127 Ubiquitination PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
Y150 Phosphorylation PhosphoSitePlus   RLIMS-P 24789045
S184 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 22615398
S184 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus 22615398
S200 Phosphorylation PhosphoSitePlus
S201 Phosphorylation PhosphoSitePlus
S202 Phosphorylation PhosphoSitePlus
T203 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O75496 (GMNN) T25 Q9H211 (CDT1) unknown eFIP 23695679


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S34 F34 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S60 P60 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S60 C60 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
T61 A61 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S63 C63 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S64 R64 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
Y98 F98 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
K115 M115 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S184 Y184 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S202 F202 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]