iPTMnet Report for O75494 (SRSF10)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O75494 / SRS10_HUMAN
Protein Name Serine/arginine-rich splicing factor 10
Gene Name Name: SRSF10
Synonyms:FUSIP1,FUSIP2,SFRS13A,TASR;
Organism Homo sapiens (Human)

PRO ID PR:O75494
DAG View
PRO Name serine/arginine-rich splicing factor 10 (human)
Definition A serine/arginine-rich splicing factor 10 that is encoded in the genome of human.
Short Label hSRSF10
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75494 (SRSF10) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus
Y4 Phosphorylation PhosphoSitePlus
R6 Methylation PhosphoSitePlus
T10 Phosphorylation PhosphoSitePlus
R15 Methylation PhosphoSitePlus
T21 Phosphorylation PhosphoSitePlus
R22 Methylation PhosphoSitePlus
S23 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y40 Phosphorylation PhosphoSitePlus
Y55 Phosphorylation PhosphoSitePlus
R62 Methylation PhosphoSitePlus
C77 Methylation IEDB 31844290
K91 Methylation PhosphoSitePlus
T92 Phosphorylation PhosphoSitePlus
K99 Acetylation PhosphoSitePlus
Y105 Phosphorylation PhosphoSitePlus
S106 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692
S107 Phosphorylation PhosphoSitePlus
S108 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18669648
Y110 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y113 Phosphorylation PhosphoSitePlus
S119 Phosphorylation PhosphoSitePlus
S121 Phosphorylation PhosphoSitePlus
S123 Phosphorylation PhosphoSitePlus
S129 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18669648, 17287340
S131 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 23186163, 27851963, ...18669648, 24275569, 17287340, 20068231
S133 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 19369195, 21406692, 23186163, ...18220336, 15302935, 27851963, 18669648, 17287340, 24275569, 33180834, 27928057, 20068231
Y136 Phosphorylation PhosphoSitePlus
Y138 Phosphorylation PhosphoSitePlus
S141 Phosphorylation PhosphoSitePlus
Y142 Phosphorylation PhosphoSitePlus
S143 Phosphorylation PhosphoSitePlus
S147 Phosphorylation PhosphoSitePlus
T150 Phosphorylation PhosphoSitePlus
S156 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S158 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 20068231
S160 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 20068231
S171 Phosphorylation PhosphoSitePlus
S173 Phosphorylation PhosphoSitePlus
S175 Phosphorylation PhosphoSitePlus
S199 Phosphorylation PhosphoSitePlus
S201 Phosphorylation PhosphoSitePlus
S235 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S237 O-Glycosylation GlyGen 23301498, 30379171, 33214551, ...34019948, 30620550
S239 O-Glycosylation GlyGen 23301498, 30379171, 33214551, ...34019948, 30620550
S249 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S251 Phosphorylation PhosphoSitePlus
S253 Phosphorylation PhosphoSitePlus
T255 Phosphorylation PhosphoSitePlus
S256 Phosphorylation PhosphoSitePlus
S259 Phosphorylation PhosphoSitePlus
S260 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y105 Phosphorylation HPRD 20068231
S106 Phosphorylation HPRD 18669648, 20068231
S107 Phosphorylation HPRD 20068231
S108 Phosphorylation HPRD 18669648, 20068231
Y110 Phosphorylation HPRD 18669648, 17081983, 18452278
S119 Phosphorylation HPRD 19651622
S121 Phosphorylation HPRD 19651622, 20068231
S123 Phosphorylation HPRD 19651622, 20068231
S129 Phosphorylation HPRD 19651622, 18669648, 17287340, ...17081983
S131 Phosphorylation HPRD 18691976, 17287340, 17081983, ...18452278, 19651622, 18669648, 20166139, 20068231, 18212344
S133 Phosphorylation HPRD 19413330, 18691976, 17287340, ...18212344, 18767875, 19664994, 19664995, 18452278, 17322306, 18669648, 20058876, 19651622, 20166139, 19415658, 20068231
Y136 Phosphorylation HPRD 17081983
Y138 Phosphorylation HPRD 17081983
S141 Phosphorylation HPRD 20068231
S143 Phosphorylation HPRD 20068231
S156 Phosphorylation HPRD 19651622, 17081983, 20068231
S158 Phosphorylation HPRD 19651622, 17081983, 20068231
S160 Phosphorylation HPRD 19651622, 17081983, 20068231, ...18452278
S235 Phosphorylation HPRD 17081983
S249 Phosphorylation HPRD 19651622
S251 Phosphorylation HPRD 19651622, 17081983, 20068231
S253 Phosphorylation HPRD 19651622, 17081983
T255 Phosphorylation HPRD 19651622, 17081983, 20068231
S256 Phosphorylation HPRD 19651622, 17081983, 20068231
S259 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
Y105 Phosphorylation HPRD 20068231
S106 Phosphorylation HPRD 18669648, 20068231
S107 Phosphorylation HPRD 20068231
S108 Phosphorylation HPRD 18669648, 20068231
Y110 Phosphorylation HPRD 18669648, 17081983, 18452278
S119 Phosphorylation HPRD 19651622
S121 Phosphorylation HPRD 19651622, 20068231
S123 Phosphorylation HPRD 19651622, 20068231
S129 Phosphorylation HPRD 19651622, 18669648, 17287340, ...17081983
S131 Phosphorylation HPRD 18691976, 17287340, 17081983, ...18452278, 19651622, 18669648, 20166139, 20068231, 18212344
S133 Phosphorylation HPRD 19413330, 18691976, 17287340, ...18212344, 18767875, 19664994, 19664995, 18452278, 17322306, 18669648, 20058876, 19651622, 20166139, 19415658, 20068231
Y136 Phosphorylation HPRD 17081983
Y138 Phosphorylation HPRD 17081983
S141 Phosphorylation HPRD 20068231
S143 Phosphorylation HPRD 20068231
S156 Phosphorylation PhosphoSitePlus
S158 Phosphorylation HPRD   PhosphoSitePlus 20068231, 18452278
S160 Phosphorylation HPRD   PhosphoSitePlus 17081983, 18452278
S168 Phosphorylation PhosphoSitePlus
T171 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S156 Phosphorylation PhosphoSitePlus
S158 Phosphorylation PhosphoSitePlus
S160 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T153 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R62 C62 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R62 S62 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
Y105 H105 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S141 L141 Biomuta DOID:10534 / stomach cancer [ cosmic ]