iPTMnet Report for O75475 (PSIP1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O75475 / PSIP1_HUMAN
Protein Name PC4 and SFRS1-interacting protein
Gene Name Name: PSIP1
Synonyms:DFS70,LEDGF,PSIP2;
Organism Homo sapiens (Human)

PRO ID PR:O75475
DAG View
PRO Name PC4 and SFRS1-interacting protein (human)
Definition A PC4 and SFRS1-interacting protein that is encoded in the genome of human.
Short Label hPSIP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75475 (PSIP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K6 Ubiquitination PhosphoSitePlus
K14 Ubiquitination PhosphoSitePlus
K16 Ubiquitination PhosphoSitePlus
Y18 Phosphorylation PhosphoSitePlus
K34 Ubiquitination PhosphoSitePlus
T37 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...34019948, 29351928
S62 Phosphorylation PhosphoSitePlus
K65 Ubiquitination PhosphoSitePlus
K75 Sumoylation PhosphoSitePlus
K75 Ubiquitination PhosphoSitePlus
K89 Ubiquitination PhosphoSitePlus
K91 Ubiquitination PhosphoSitePlus
S93 Phosphorylation PhosphoSitePlus
S94 Phosphorylation PhosphoSitePlus
T99 Phosphorylation PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
S102 Phosphorylation PhosphoSitePlus
S105 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S106 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17287340, 17081983, 15302935, ...18669648, 24275569, 23186163, 20068231
T115 Phosphorylation PhosphoSitePlus
S116 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S118 Phosphorylation PhosphoSitePlus
T122 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18669648, ...24275569, 17287340, 20068231
S129 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...24275569, 17287340
K135 Ubiquitination PhosphoSitePlus
T140 Phosphorylation PhosphoSitePlus
T141 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 16964243, 18669648, ...19690332, 20068231
K143 Ubiquitination PhosphoSitePlus
T159 Phosphorylation PhosphoSitePlus
T166 Phosphorylation PhosphoSitePlus
T167 Phosphorylation PhosphoSitePlus   UniProt 19690332
T169 Phosphorylation PhosphoSitePlus
S171 Phosphorylation PhosphoSitePlus
S177 Phosphorylation PhosphoSitePlus   UniProt 21406692, 19690332
T186 Phosphorylation PhosphoSitePlus
K201 Methylation PhosphoSitePlus
K201 Ubiquitination PhosphoSitePlus
C204 S-Nitrosylation dbSNO 26338901
S206 O-Glycosylation GlyGen 23301498, 33214551, 28510447, ...34019948, 29351928
S206 Phosphorylation PhosphoSitePlus   RLIMS-P   Signor   UniProt 19864417, 21406692, 7231784, ...20068231
S206 Phosphorylation O00311 (CDC7) PhosphoSitePlus   Signor 19864417, 7231784
S208 Phosphorylation PhosphoSitePlus
T212 Phosphorylation PhosphoSitePlus
K216 Acetylation PhosphoSitePlus
K220 Acetylation PhosphoSitePlus
K225 Acetylation PhosphoSitePlus
K228 Acetylation PhosphoSitePlus
K229 Acetylation PhosphoSitePlus
K232 Acetylation PhosphoSitePlus
K250 Sumoylation PhosphoSitePlus
K254 Sumoylation PhosphoSitePlus
T267 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T270 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S271 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 16083285, 24275569
T272 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 24275569
S273 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18669648, ...24275569, 17287340, 19690332, 20068231
S275 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 16083285, 23186163, ...17081983, 18669648, 24275569, 17287340, 19690332, 20068231
T324 Phosphorylation PhosphoSitePlus
T346 Phosphorylation PhosphoSitePlus
S347 Phosphorylation PhosphoSitePlus
S350 Phosphorylation PhosphoSitePlus
K360 Ubiquitination PhosphoSitePlus
K364 Sumoylation PhosphoSitePlus
K364 Ubiquitination PhosphoSitePlus
K401 Ubiquitination PhosphoSitePlus
K407 Ubiquitination PhosphoSitePlus
K415 Ubiquitination PhosphoSitePlus
K422 Ubiquitination PhosphoSitePlus
K424 Ubiquitination PhosphoSitePlus
S434 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
T437 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332
K442 Ubiquitination PhosphoSitePlus
S443 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
K461 Acetylation PhosphoSitePlus
K462 Acetylation PhosphoSitePlus
K466 Acetylation PhosphoSitePlus
S482 Phosphorylation PhosphoSitePlus
S496 Phosphorylation PhosphoSitePlus
S500 Phosphorylation PhosphoSitePlus
S513 Phosphorylation PhosphoSitePlus
S514 Phosphorylation PhosphoSitePlus   UniProt 23186163
T519 Phosphorylation PhosphoSitePlus
S522 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
K524 Ubiquitination PhosphoSitePlus
S526 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T527 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S62 Phosphorylation HPRD 20068231
S93 Phosphorylation HPRD 18452278
S102 Phosphorylation HPRD 19651622, 20068231, 18452278
S105 Phosphorylation HPRD 19413330, 19651622, 18669648, ...17081983
S106 Phosphorylation HPRD 19413330, 17287340, 15302935, ...18452278, 19651622, 18669648, 20068231
T115 Phosphorylation HPRD 19651622, 20068231, 18452278
S116 Phosphorylation HPRD 19651622, 18669648
S118 Phosphorylation HPRD 20068231
T122 Phosphorylation HPRD 17287340, 17081983, 18452278, ...19651622, 18669648, 20068231
S129 Phosphorylation HPRD 19651622, 17287340, 20068231
T140 Phosphorylation HPRD 17081983, 20068231
T141 Phosphorylation HPRD 19413330, 18212344, 19664995, ...18669648, 20068230, 20068231, 16964243
T159 Phosphorylation HPRD 18452278
T169 Phosphorylation HPRD 18452278
S171 Phosphorylation HPRD 18452278
S177 Phosphorylation HPRD 20068231, 18452278
S206 Phosphorylation HPRD 20068231
T267 Phosphorylation HPRD 18669648, 17081983
T270 Phosphorylation HPRD 19413330, 18669648, 17081983
S271 Phosphorylation HPRD 18669648, 19415658
T272 Phosphorylation HPRD 19413330, 18669648, 19415658, ...20068231
S273 Phosphorylation HPRD 19413330, 17287340, 17081983, ...18452278, 19651622, 18669648, 20166139, 19415658, 20068231
S275 Phosphorylation HPRD 19413330, 16083285, 17287340, ...18452278, 19651622, 18669648, 20166139, 19415658, 20068231
T398 Phosphorylation HPRD 20068231
S434 Phosphorylation HPRD 18669648, 20068231
T437 Phosphorylation HPRD 17525332
S443 Phosphorylation HPRD 18669648, 20068231
T508 Phosphorylation HPRD 20068231
T519 Phosphorylation HPRD 17081983, 18452278
S522 Phosphorylation HPRD 18669648, 20068231, 18452278
S526 Phosphorylation HPRD 18669648
T527 Phosphorylation HPRD 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S62 Phosphorylation HPRD 20068231
K75 Sumoylation PhosphoSitePlus
S93 Phosphorylation HPRD 18452278
S102 Phosphorylation HPRD 19651622, 20068231, 18452278
S105 Phosphorylation HPRD 19413330, 19651622, 18669648, ...17081983
S106 Phosphorylation HPRD 19413330, 17287340, 15302935, ...18452278, 19651622, 18669648, 20068231
T115 Phosphorylation HPRD 19651622, 20068231, 18452278
S116 Phosphorylation HPRD 19651622, 18669648
S118 Phosphorylation HPRD 20068231
T122 Phosphorylation HPRD 17287340, 17081983, 18452278, ...19651622, 18669648, 20068231
S129 Phosphorylation HPRD 19651622, 17287340, 20068231
T140 Phosphorylation HPRD 17081983, 20068231
T141 Phosphorylation HPRD 19413330, 18212344, 19664995, ...18669648, 20068230, 20068231, 16964243
T159 Phosphorylation HPRD 18452278
T169 Phosphorylation HPRD 18452278
S171 Phosphorylation HPRD 18452278
S177 Phosphorylation HPRD 20068231, 18452278
S206 Phosphorylation HPRD 20068231
K250 Sumoylation PhosphoSitePlus
K254 Sumoylation PhosphoSitePlus
T267 Phosphorylation HPRD 18669648, 17081983
T270 Phosphorylation HPRD 19413330, 18669648, 17081983
S271 Phosphorylation HPRD 18669648, 19415658
T272 Phosphorylation HPRD 19413330, 18669648, 19415658, ...20068231
S273 Phosphorylation HPRD 19413330, 17287340, 17081983, ...18452278, 19651622, 18669648, 20166139, 19415658, 20068231
S275 Phosphorylation HPRD 19413330, 16083285, 17287340, ...18452278, 19651622, 18669648, 20166139, 19415658, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S62 * Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S93 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic, tcga ]
T99 A99 Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, cosmic ] DOID:2531 / hematologic cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic, cosmic ] DOID:5041 / esophageal cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic ]
S102 * Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S118 * Biomuta DOID:1324 / lung cancer [ cosmic ]
T140 S140 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S171 Y171 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
K220 R220 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T270 S270 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T324 A324 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T346 A346 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S347 L347 Biomuta DOID:1612 / breast cancer [ cosmic ]
K364 R364 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S443 Y443 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S482 Y482 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
T527 K527 Biomuta DOID:4159 / skin cancer [ cosmic ]