iPTMnet Report for O75469 (NR1I2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O75469 / NR1I2_HUMAN
Protein Name Nuclear receptor subfamily 1 group I member 2
Gene Name Name: NR1I2
Synonyms:PXR;
Organism Homo sapiens (Human)

PRO ID PR:O75469
DAG View
PRO Name nuclear receptor subfamily 1 group I member 2 (human)
Definition A nuclear receptor subfamily 1 group I member 2 that is encoded in the genome of human.
Short Label hNR1I2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75469 (NR1I2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S8 Phosphorylation PhosphoSitePlus
T57 Phosphorylation PhosphoSitePlus
K101 Ubiquitination PhosphoSitePlus
K109 Acetylation PhosphoSitePlus
S114 Phosphorylation P24941 (CDK2) PhosphoSitePlus   RLIMS-P 24184507
T133 Phosphorylation P24941 (CDK2) PhosphoSitePlus   RLIMS-P 24184507
T135 Phosphorylation P24941 (CDK2) PhosphoSitePlus   RLIMS-P 24184507
S167 Phosphorylation P24941 (CDK2) PhosphoSitePlus   RLIMS-P 24184507
K170 Acetylation PhosphoSitePlus
S200 Phosphorylation P24941 (CDK2) PhosphoSitePlus   RLIMS-P 24184507
S208 Phosphorylation PhosphoSitePlus
S221 Phosphorylation PhosphoSitePlus
T248 Phosphorylation PhosphoSitePlus   RLIMS-P 22976785
Y249 Phosphorylation PhosphoSitePlus   RLIMS-P 22976785
S256 Phosphorylation PhosphoSitePlus
S274 Phosphorylation PhosphoSitePlus
T290 Phosphorylation PhosphoSitePlus   RLIMS-P 25074870
S305 Phosphorylation PhosphoSitePlus
S350 Phosphorylation P24941 (CDK2) PhosphoSitePlus   RLIMS-P 28911860, 26119819, 22829544, ...32798464, 35053380, 18784074
T408 Phosphorylation P17252 (PRKCA) PhosphoSitePlus   RLIMS-P 26534988
T422 Phosphorylation PhosphoSitePlus   RLIMS-P 22976785


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S114 T114 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S200 N200 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y249 F249 Biomuta DOID:3571 / liver cancer [ cosmic ]
S256 N256 Biomuta DOID:2394 / ovarian cancer [ cosmic ]