iPTMnet Report for O75461 (E2F6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O75461 / E2F6_HUMAN
Protein Name Transcription factor E2F6
Gene Name Name: E2F6
Organism Homo sapiens (Human)

PRO ID PR:O75461
DAG View
PRO Name transcription factor E2F6 (human)
Definition A transcription factor E2F6 that is encoded in the genome of human.
Short Label hE2F6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75461 (E2F6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K9 Ubiquitination PhosphoSitePlus
S12 Phosphorylation O14757 (CHEK1) PhosphoSitePlus 23954429
T21 Phosphorylation PhosphoSitePlus
Y50 Phosphorylation PhosphoSitePlus
S52 Phosphorylation O14757 (CHEK1) PhosphoSitePlus 23954429
K74 Acetylation PhosphoSitePlus
K91 Acetylation PhosphoSitePlus
K95 Acetylation PhosphoSitePlus
K95 Ubiquitination PhosphoSitePlus
K100 Acetylation PhosphoSitePlus
K118 Ubiquitination PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
K175 Ubiquitination PhosphoSitePlus
T184 Phosphorylation IEDB 35494241
T221 Phosphorylation PhosphoSitePlus
S226 Phosphorylation PhosphoSitePlus
T243 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y50 F50 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S52 F52 Biomuta DOID:4159 / skin cancer [ cosmic ]