iPTMnet Report for O75460 (ERN1)
Protein Information
UniProt AC / UniProt ID | O75460 / ERN1_HUMAN |
Protein Name | Serine/threonine-protein kinase/endoribonuclease IRE1 precursor |
Gene Name | Name: ERN1 Synonyms:IRE1; |
Organism | Homo sapiens (Human) |
PRO ID | PR:O75460 |
PRO Name | serine/threonine-protein kinase/endoribonuclease IRE1 (human) |
Definition | A serine/threonine-protein kinase/endoribonuclease IRE1 that is encoded in the genome of human. |
Short Label | hERN1 |
Category | organism-gene |
O75460 (ERN1) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
T49 | Phosphorylation | score1 | PhosphoSitePlus | |||
K88 | Ubiquitination | score1 | PhosphoSitePlus | |||
K95 | Ubiquitination | score1 | PhosphoSitePlus | |||
T132 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y161 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y166 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y179 | Phosphorylation | score1 | PhosphoSitePlus | |||
T283 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y289 | Phosphorylation | score1 | PhosphoSitePlus | |||
K374 | Acetylation | score1 | PhosphoSitePlus | |||
K374 | Ubiquitination | score1 | PhosphoSitePlus | |||
K485 | Ubiquitination | score1 | PhosphoSitePlus | |||
S533 | Phosphorylation | score1 | PhosphoSitePlus | |||
S536 | Phosphorylation | score1 | PhosphoSitePlus | |||
S544 | Phosphorylation | score1 | PhosphoSitePlus | |||
S548 | Phosphorylation | score1 | PhosphoSitePlus | |||
S551 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y628 | Phosphorylation | O75460 (ERN1) | score3 | PhosphoSitePlus RLIMS-P | 25968568 | |
K633 | Ubiquitination | score1 | PhosphoSitePlus | |||
K706 | Ubiquitination | score1 | PhosphoSitePlus | |||
S724 | Phosphorylation | O75460 (ERN1) | score4 | IntAct neXtProt PhosphoSitePlus RLIMS-P | 25870107, 21911379, 24704861, ... | |
S726 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 24704861 | ||
S729 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 24704861 | ||
S769 | Phosphorylation | score0 | RLIMS-P | 29311133 | ||
K851 | Ubiquitination | score1 | PhosphoSitePlus | |||
K860 | Ubiquitination | score1 | PhosphoSitePlus | |||
T973 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 19369195 |
O75460 (ERN1) as PTM Enzyme
PTM-dependent PPI
PTM type | Substrate | Site | Interactant | Association type | Source | PMID | |
---|---|---|---|---|---|---|---|
Phosphorylation | O75460 (ERN1) | S724 | unknown | eFIP | 21317875 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
K374 | N374 | Biomuta | DOID:363 / uterine cancer [ tcga ] | |
S536 | T536 | Biomuta | DOID:3963 / thyroid carcinoma [ cosmic, icgc ] | |
S536 | L536 | Biomuta | DOID:363 / uterine cancer [ tcga ] | |
K633 | Q633 | Biomuta | DOID:3070 / malignant glioma [ tcga ] |