iPTMnet Report for O75460 (ERN1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O75460 / ERN1_HUMAN
Protein Name Serine/threonine-protein kinase/endoribonuclease IRE1 precursor
Gene Name Name: ERN1
Synonyms:IRE1;
Organism Homo sapiens (Human)

PRO ID PR:O75460
DAG View
PRO Name serine/threonine-protein kinase/endoribonuclease IRE1 (human)
Definition A serine/threonine-protein kinase/endoribonuclease IRE1 that is encoded in the genome of human.
Short Label hERN1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75460 (ERN1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T49 Phosphorylation PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
K95 Ubiquitination PhosphoSitePlus
T132 Phosphorylation PhosphoSitePlus
Y161 Phosphorylation PhosphoSitePlus
Y166 Phosphorylation PhosphoSitePlus
Y179 Phosphorylation PhosphoSitePlus
T283 Phosphorylation PhosphoSitePlus
Y289 Phosphorylation PhosphoSitePlus
K374 Acetylation PhosphoSitePlus
K374 Ubiquitination PhosphoSitePlus
T417 O-Glycosylation GlyGen 25813380
K485 Ubiquitination PhosphoSitePlus
S533 Phosphorylation PhosphoSitePlus
S536 Phosphorylation PhosphoSitePlus
S544 Phosphorylation PhosphoSitePlus
S548 Phosphorylation PhosphoSitePlus
S551 Phosphorylation PhosphoSitePlus
Y628 Phosphorylation O75460 (ERN1) PhosphoSitePlus   RLIMS-P 25968568
K633 Ubiquitination PhosphoSitePlus
K706 Ubiquitination PhosphoSitePlus
S724 Phosphorylation O75460 (ERN1) IntAct   neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 25870107, 21911379, 24704861, ...21317875, 30118681, 25692299, 25685256
S726 Phosphorylation PhosphoSitePlus   RLIMS-P 24704861
S729 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 30118681, 24704861
S769 Phosphorylation RLIMS-P 29311133
K851 Ubiquitination PhosphoSitePlus
K860 Ubiquitination PhosphoSitePlus
T973 Phosphorylation PhosphoSitePlus   UniProt 19369195


O75460 (ERN1) as PTM Enzyme



Substrate Site Score Source PMID
O75460 (ERN1) Y628 PhosphoSitePlus 25968568
O75460 (ERN1) S724 neXtProt 21317875


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K374 N374 Biomuta DOID:363 / uterine cancer [ icgc ]
T417 I417 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S536 T536 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S536 L536 Biomuta DOID:363 / uterine cancer [ icgc ]
K633 Q633 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]