Protein Information

Cytoscape View


UniProt AC / UniProt ID O75448 / MED24_HUMAN
Protein Name Mediator of RNA polymerase II transcription subunit 24
Gene Name Name: MED24
Synonyms:ARC100,CRSP4,DRIP100,KIAA0130,THRAP4,TRAP100;
Organism Homo sapiens (Human)

PRO ID PR:O75448
DAG View
PRO Name mediator of RNA polymerase II transcription subunit 24 (human)
Definition A mediator of RNA polymerase II transcription subunit 24 that is encoded in the genome of human.
Short Label hMED24
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75448 (MED24) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T36 Phosphorylation PhosphoSitePlus
Y66 Phosphorylation PhosphoSitePlus
Y75 Phosphorylation PhosphoSitePlus
K156 Ubiquitination PhosphoSitePlus
K167 Ubiquitination PhosphoSitePlus
T172 Phosphorylation PhosphoSitePlus
K350 Ubiquitination PhosphoSitePlus
T360 Phosphorylation PhosphoSitePlus
S374 Phosphorylation PhosphoSitePlus
S377 Phosphorylation PhosphoSitePlus
K384 Ubiquitination PhosphoSitePlus
S397 Phosphorylation PhosphoSitePlus
K422 Ubiquitination PhosphoSitePlus
T423 Phosphorylation PhosphoSitePlus
S429 Phosphorylation PhosphoSitePlus
S444 Phosphorylation PhosphoSitePlus
S447 Phosphorylation PhosphoSitePlus
K460 Ubiquitination PhosphoSitePlus
K484 Ubiquitination PhosphoSitePlus
K638 Ubiquitination PhosphoSitePlus
S652 Phosphorylation PhosphoSitePlus
T655 Phosphorylation PhosphoSitePlus
K717 Ubiquitination PhosphoSitePlus
K721 Ubiquitination PhosphoSitePlus
K856 Ubiquitination PhosphoSitePlus
S862 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...15302935, 18669648, 19690332, 20068231
S863 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S872 Phosphorylation PhosphoSitePlus
S873 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18669648, ...19690332, 20068231
T875 Phosphorylation PhosphoSitePlus
K965 Ubiquitination PhosphoSitePlus
T971 Phosphorylation PhosphoSitePlus
K984 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T172 Phosphorylation HPRD 20068231
S374 Phosphorylation HPRD 20068231
S377 Phosphorylation HPRD 20068231
S397 Phosphorylation HPRD 20068231
S447 Phosphorylation HPRD 20068231
S862 Phosphorylation HPRD 19413330, 18691976, 20058876, ...15302935, 18452278, 19651622, 18669648, 20068231
S863 Phosphorylation HPRD 18669648, 20068231
S872 Phosphorylation HPRD 18691976
S873 Phosphorylation HPRD 19413330, 18691976, 20058876, ...19664994, 19664995, 18452278, 19651622, 18669648, 19415658, 20068231
T875 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
T159 Phosphorylation HPRD 20068231
S361 Phosphorylation HPRD 20068231
S364 Phosphorylation HPRD 20068231
S384 Phosphorylation HPRD 20068231
S434 Phosphorylation HPRD 20068231
S849 Phosphorylation HPRD 19413330, 18691976, 20058876, ...18452278, 19651622, 18669648, 20068231
S850 Phosphorylation HPRD 18669648, 20068231
S859 Phosphorylation HPRD 18691976
S860 Phosphorylation HPRD 19413330, 18691976, 20058876, ...19664994, 19664995, 18452278, 19651622, 18669648, 19415658, 20068231
T862 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T360 K360 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S397 L397 Biomuta DOID:4362 / cervical cancer [ tcga ]
S444 F444 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S862 R862 Biomuta DOID:1612 / breast cancer [ tcga ]
S873 T873 Biomuta DOID:3963 / thyroid carcinoma [ cosmic ]
T971 M971 Biomuta DOID:5041 / esophageal cancer [ icgc ]