iPTMnet Report for O75448 (MED24)
Protein Information
UniProt AC / UniProt ID | O75448 / MED24_HUMAN |
Protein Name | Mediator of RNA polymerase II transcription subunit 24 |
Gene Name | Name: MED24 Synonyms:ARC100,CRSP4,DRIP100,KIAA0130,THRAP4,TRAP100; |
Organism | Homo sapiens (Human) |
PRO ID | PR:O75448 |
PRO Name | mediator of RNA polymerase II transcription subunit 24 (human) |
Definition | A mediator of RNA polymerase II transcription subunit 24 that is encoded in the genome of human. |
Short Label | hMED24 |
Category | organism-gene |
O75448 (MED24) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
T36 | Phosphorylation | score1 | PhosphoSitePlus | |||
S62 | Phosphorylation | score1 | IEDB | 32387766 | ||
Y66 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y75 | Phosphorylation | score1 | PhosphoSitePlus | |||
K156 | Ubiquitination | score1 | PhosphoSitePlus | |||
K167 | Ubiquitination | score1 | PhosphoSitePlus | |||
T172 | Phosphorylation | score1 | PhosphoSitePlus | |||
K350 | Ubiquitination | score1 | PhosphoSitePlus | |||
T360 | Phosphorylation | score1 | PhosphoSitePlus | |||
S374 | Phosphorylation | score1 | PhosphoSitePlus | |||
S377 | Phosphorylation | score1 | PhosphoSitePlus | |||
K384 | Ubiquitination | score1 | PhosphoSitePlus | |||
S397 | Phosphorylation | score1 | PhosphoSitePlus | |||
K422 | Ubiquitination | score1 | PhosphoSitePlus | |||
T423 | Phosphorylation | score1 | PhosphoSitePlus | |||
S429 | Phosphorylation | score1 | PhosphoSitePlus | |||
S444 | Phosphorylation | score1 | PhosphoSitePlus | |||
S447 | Phosphorylation | score1 | PhosphoSitePlus | |||
K460 | Ubiquitination | score1 | PhosphoSitePlus | |||
K484 | Ubiquitination | score1 | PhosphoSitePlus | |||
C578 | Methylation | score1 | IEDB | 31844290 | ||
K638 | Ubiquitination | score1 | PhosphoSitePlus | |||
S652 | Phosphorylation | score1 | PhosphoSitePlus | |||
T655 | Phosphorylation | score1 | PhosphoSitePlus | |||
K717 | Ubiquitination | score1 | PhosphoSitePlus | |||
K721 | Ubiquitination | score1 | PhosphoSitePlus | |||
K856 | Ubiquitination | score1 | PhosphoSitePlus | |||
S862 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 21406692, 23186163, 17081983, ... | ||
S863 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
S872 | Phosphorylation | score1 | PhosphoSitePlus | |||
S873 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 23186163, 17081983, 18669648, ... | ||
T875 | Phosphorylation | score1 | PhosphoSitePlus | |||
K965 | Ubiquitination | score1 | PhosphoSitePlus | |||
T971 | Phosphorylation | score1 | PhosphoSitePlus | |||
K984 | Ubiquitination | score1 | PhosphoSitePlus |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
T172 | Phosphorylation | score0 | HPRD | 20068231 | ||
S374 | Phosphorylation | score0 | HPRD | 20068231 | ||
S377 | Phosphorylation | score0 | HPRD | 20068231 | ||
S397 | Phosphorylation | score0 | HPRD | 20068231 | ||
S447 | Phosphorylation | score0 | HPRD | 20068231 | ||
S862 | Phosphorylation | score0 | HPRD | 19413330, 18691976, 20058876, ... | ||
S863 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
S872 | Phosphorylation | score0 | HPRD | 18691976 | ||
S873 | Phosphorylation | score0 | HPRD | 19413330, 18691976, 20058876, ... | ||
T875 | Phosphorylation | score0 | HPRD | 20068231 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
T159 | Phosphorylation | score0 | HPRD | 20068231 | ||
S361 | Phosphorylation | score0 | HPRD | 20068231 | ||
S364 | Phosphorylation | score0 | HPRD | 20068231 | ||
S384 | Phosphorylation | score0 | HPRD | 20068231 | ||
S434 | Phosphorylation | score0 | HPRD | 20068231 | ||
S849 | Phosphorylation | score0 | HPRD | 19413330, 18691976, 20058876, ... | ||
S850 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
S859 | Phosphorylation | score0 | HPRD | 18691976 | ||
S860 | Phosphorylation | score0 | HPRD | 19413330, 18691976, 20058876, ... | ||
T862 | Phosphorylation | score0 | HPRD | 20068231 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
T36 | S36 | Biomuta | DOID:1319 / brain cancer [ cosmic ] | |
T360 | K360 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
S384 | L384 | Biomuta | DOID:4159 / skin cancer [ cosmic ] DOID:4362 / cervical cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ] | |
S397 | L397 | Biomuta | DOID:4159 / skin cancer [ cosmic ] DOID:4362 / cervical cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ] | |
T423 | M423 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
S444 | F444 | Biomuta | [ cosmic ] DOID:4159 / skin cancer [ cosmic, icgc ] | |
C578 | S578 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
S860 | T860 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] | |
S873 | T873 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] |