iPTMnet Report for O75448 (MED24)
Protein Information
| UniProt AC / UniProt ID | O75448 / MED24_HUMAN |
| Protein Name | Mediator of RNA polymerase II transcription subunit 24 |
| Gene Name | Name: MED24 Synonyms:ARC100,CRSP4,DRIP100,KIAA0130,THRAP4,TRAP100; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:O75448 |
| PRO Name | mediator of RNA polymerase II transcription subunit 24 (human) |
| Definition | A mediator of RNA polymerase II transcription subunit 24 that is encoded in the genome of human. |
| Short Label | hMED24 |
| Category | organism-gene |
O75448 (MED24) as Substrate
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| T36 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S62 | Phosphorylation | score1 | IEDB | 32387766 | ||
| Y66 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y75 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K156 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K167 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T172 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K350 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T360 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S374 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S377 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K384 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S397 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K422 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T423 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S429 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S444 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S447 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K460 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K484 | Ubiquitination | score1 | PhosphoSitePlus | |||
| C578 | Methylation | score1 | IEDB | 31844290 | ||
| K638 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S652 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T655 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K717 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K721 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K856 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S862 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 21406692, 23186163, 17081983, ... | ||
| S863 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
| S872 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S873 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 23186163, 17081983, 18669648, ... | ||
| T875 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K965 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T971 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K984 | Ubiquitination | score1 | PhosphoSitePlus |
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| T172 | Phosphorylation | score0 | HPRD | 20068231 | ||
| S374 | Phosphorylation | score0 | HPRD | 20068231 | ||
| S377 | Phosphorylation | score0 | HPRD | 20068231 | ||
| S397 | Phosphorylation | score0 | HPRD | 20068231 | ||
| S447 | Phosphorylation | score0 | HPRD | 20068231 | ||
| S862 | Phosphorylation | score0 | HPRD | 19413330, 18691976, 20058876, ... | ||
| S863 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
| S872 | Phosphorylation | score0 | HPRD | 18691976 | ||
| S873 | Phosphorylation | score0 | HPRD | 19413330, 18691976, 20058876, ... | ||
| T875 | Phosphorylation | score0 | HPRD | 20068231 |
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| T159 | Phosphorylation | score0 | HPRD | 20068231 | ||
| S361 | Phosphorylation | score0 | HPRD | 20068231 | ||
| S364 | Phosphorylation | score0 | HPRD | 20068231 | ||
| S384 | Phosphorylation | score0 | HPRD | 20068231 | ||
| S434 | Phosphorylation | score0 | HPRD | 20068231 | ||
| S849 | Phosphorylation | score0 | HPRD | 19413330, 18691976, 20058876, ... | ||
| S850 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
| S859 | Phosphorylation | score0 | HPRD | 18691976 | ||
| S860 | Phosphorylation | score0 | HPRD | 19413330, 18691976, 20058876, ... | ||
| T862 | Phosphorylation | score0 | HPRD | 20068231 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| T36 | S36 | Biomuta | DOID:1319 / brain cancer [ cosmic ] | |
| T360 | K360 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| S384 | L384 | Biomuta | DOID:4159 / skin cancer [ cosmic ] DOID:4362 / cervical cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ] | |
| S397 | L397 | Biomuta | DOID:4159 / skin cancer [ cosmic ] DOID:4362 / cervical cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ] | |
| T423 | M423 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| S444 | F444 | Biomuta | [ cosmic ] DOID:4159 / skin cancer [ cosmic, icgc ] | |
| C578 | S578 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| S860 | T860 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] | |
| S873 | T873 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] |
DAG View