iPTMnet Report for O75439 (PMPCB)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O75439 / MPPB_HUMAN
Protein Name Mitochondrial-processing peptidase subunit beta precursor
Gene Name Name: PMPCB
Synonyms:MPPB;
Organism Homo sapiens (Human)

PRO ID PR:O75439
DAG View
PRO Name mitochondrial-processing peptidase subunit beta (human)
Definition A mitochondrial-processing peptidase subunit beta that is encoded in the genome of human.
Short Label hPMPCB
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75439 (PMPCB) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S11 Phosphorylation PhosphoSitePlus
S12 Phosphorylation PhosphoSitePlus
S44 Phosphorylation PhosphoSitePlus
T45 Phosphorylation PhosphoSitePlus
T49 Phosphorylation PhosphoSitePlus
T58 Phosphorylation PhosphoSitePlus
C62 S-Nitrosylation dbSNO 26338901
K95 Ubiquitination PhosphoSitePlus
T111 O-Glycosylation GlyGen 36580660, 30379171, 34229054, ...29351928, 32870666, 28510447, 33465208
Y133 Phosphorylation PhosphoSitePlus
Y141 Phosphorylation PhosphoSitePlus
Y142 Phosphorylation PhosphoSitePlus
K148 Ubiquitination PhosphoSitePlus
T205 Phosphorylation PhosphoSitePlus
T215 O-Glycosylation GlyGen 36580660, 30379171, 34229054, ...29351928, 32870666, 28510447, 33465208
K219 Ubiquitination PhosphoSitePlus
S220 O-Glycosylation GlyGen 33465208
K224 Ubiquitination PhosphoSitePlus
Y229 Phosphorylation PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
C419 S-Nitrosylation dbSNO 26338901
C454 Methylation IEDB 31844290
K472 Ubiquitination PhosphoSitePlus
K478 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
C62 Y62 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y133 C133 Biomuta DOID:1319 / brain cancer [ cosmic ]
Y141 * Biomuta DOID:1324 / lung cancer [ cosmic ]
Y142 H142 Biomuta DOID:10283 / prostate cancer [ cosmic ]