iPTMnet Report for O75427 (LRCH4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O75427 / LRCH4_HUMAN
Protein Name Leucine-rich repeat and calponin homology domain-containing protein 4
Gene Name Name: LRCH4
Synonyms:LRN,LRRN1,LRRN4;
Organism Homo sapiens (Human)

PRO ID PR:O75427
DAG View
PRO Name leucine-rich repeat and calponin homology domain-containing protein 4 (human)
Definition A leucine-rich repeat and calponin homology domain-containing protein 4 that is encoded in the genome of human.
Short Label hLRCH4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75427 (LRCH4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S21 Phosphorylation PhosphoSitePlus
S25 Phosphorylation HPRD   PhosphoSitePlus 20058876
S64 Phosphorylation PhosphoSitePlus
S68 O-Glycosylation GlyGen 29351928
T71 O-Glycosylation GlyGen 29351928
S97 Phosphorylation PhosphoSitePlus
Y99 Phosphorylation PhosphoSitePlus
K147 Ubiquitination PhosphoSitePlus
S182 Phosphorylation HPRD 17081983
S183 Phosphorylation HPRD   PhosphoSitePlus 17081983
C213 Methylation IEDB 31844290
S241 Phosphorylation PhosphoSitePlus
K251 Ubiquitination PhosphoSitePlus
K256 Ubiquitination PhosphoSitePlus
S267 Phosphorylation PhosphoSitePlus
S281 Phosphorylation PhosphoSitePlus
Y294 Phosphorylation PhosphoSitePlus
S304 Phosphorylation PhosphoSitePlus   UniProt 23186163
S307 Phosphorylation PhosphoSitePlus   UniProt 23186163
S309 Phosphorylation PhosphoSitePlus   UniProt 23186163
K310 Ubiquitination PhosphoSitePlus
S313 Phosphorylation PhosphoSitePlus
S317 Phosphorylation PhosphoSitePlus
K342 Ubiquitination PhosphoSitePlus
S346 Phosphorylation PhosphoSitePlus
S380 Phosphorylation PhosphoSitePlus
S432 Phosphorylation PhosphoSitePlus   UniProt 23186163
K435 Methylation PhosphoSitePlus
K435 Ubiquitination PhosphoSitePlus
S449 Phosphorylation PhosphoSitePlus
S457 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S500 Phosphorylation PhosphoSitePlus
S506 Phosphorylation PhosphoSitePlus
S511 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
S512 Phosphorylation PhosphoSitePlus
S513 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S515 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S517 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
S520 Phosphorylation PhosphoSitePlus
S521 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 18220336
S524 Phosphorylation PhosphoSitePlus
Y531 Phosphorylation PhosphoSitePlus
S550 Phosphorylation PhosphoSitePlus
S581 Phosphorylation PhosphoSitePlus
S589 Phosphorylation PhosphoSitePlus   UniProt 23186163
K599 Ubiquitination PhosphoSitePlus
K602 Ubiquitination PhosphoSitePlus
S623 Phosphorylation PhosphoSitePlus
K643 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S68 L68 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K147 E147 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S183 F183 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
C213 R213 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S267 L267 Biomuta DOID:4159 / skin cancer [ cosmic ]
S307 T307 Biomuta [ cosmic ]
S317 L317 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K342 R342 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S346 L346 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S432 C432 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S515 G515 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S524 F524 Biomuta DOID:4159 / skin cancer [ cosmic ]
S581 F581 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S623 L623 Biomuta DOID:10534 / stomach cancer [ cosmic ]