iPTMnet Report for O75419 (CDC45)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O75419 / CDC45_HUMAN
Protein Name Cell division control protein 45 homolog
Gene Name Name: CDC45
Synonyms:CDC45L,CDC45L2;ORFNames:UNQ374/PRO710;
Organism Homo sapiens (Human)

PRO ID PR:O75419
DAG View
PRO Name cell division control protein 45 homolog (human)
Definition A CDC45-related protein that is encoded in the genome of human.
Short Label hCDC45
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75419 (CDC45) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K8 Ubiquitination PhosphoSitePlus
S16 Phosphorylation PhosphoSitePlus
K120 Sumoylation PhosphoSitePlus
Y130 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S144 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S148 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S151 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T168 Phosphorylation PhosphoSitePlus
K237 Ubiquitination PhosphoSitePlus
T262 Phosphorylation PhosphoSitePlus
K301 Ubiquitination PhosphoSitePlus
K309 Ubiquitination PhosphoSitePlus
K323 Ubiquitination PhosphoSitePlus
K326 Ubiquitination PhosphoSitePlus
K328 Ubiquitination PhosphoSitePlus
K337 Ubiquitination PhosphoSitePlus
K350 Ubiquitination PhosphoSitePlus
K354 Ubiquitination PhosphoSitePlus
T360 Phosphorylation PhosphoSitePlus
K411 Ubiquitination PhosphoSitePlus
Y413 Phosphorylation PhosphoSitePlus
K420 Ubiquitination PhosphoSitePlus
K471 Ubiquitination PhosphoSitePlus
K475 Ubiquitination PhosphoSitePlus
K482 Ubiquitination PhosphoSitePlus
T513 Phosphorylation PhosphoSitePlus
R524 Methylation PhosphoSitePlus
K528 Sumoylation PhosphoSitePlus
K528 Ubiquitination PhosphoSitePlus
K550 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y130 Phosphorylation HPRD 18669648
S144 Phosphorylation HPRD 18669648
S148 Phosphorylation HPRD 18669648
S151 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K309 R309 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K350 R350 Biomuta DOID:1324 / lung cancer [ cosmic ]
K354 N354 Biomuta DOID:363 / uterine cancer [ cosmic ]
Y413 C413 Biomuta DOID:363 / uterine cancer [ icgc ]
R524 K524 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K550 R550 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]