iPTMnet Report for O75417 (POLQ)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O75417 / DPOLQ_HUMAN
Protein Name DNA polymerase theta
Gene Name Name: POLQ
Synonyms:POLH;
Organism Homo sapiens (Human)

PRO ID PR:O75417
DAG View
PRO Name DNA polymerase theta (human)
Definition A DNA polymerase theta that is encoded in the genome of human.
Short Label hPOLQ
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75417 (POLQ) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S15 Phosphorylation PhosphoSitePlus
S23 Phosphorylation PhosphoSitePlus
Y84 Phosphorylation PhosphoSitePlus
T117 Phosphorylation PhosphoSitePlus
Y171 Phosphorylation PhosphoSitePlus
S176 Phosphorylation PhosphoSitePlus
K308 Ubiquitination PhosphoSitePlus
K475 Ubiquitination PhosphoSitePlus
K484 Ubiquitination PhosphoSitePlus
K497 Ubiquitination PhosphoSitePlus
K513 Ubiquitination PhosphoSitePlus
T557 Phosphorylation PhosphoSitePlus
S750 Phosphorylation PhosphoSitePlus
K844 Ubiquitination PhosphoSitePlus
S925 Phosphorylation PhosphoSitePlus
K928 Ubiquitination PhosphoSitePlus
K950 Ubiquitination PhosphoSitePlus
S952 Phosphorylation PhosphoSitePlus
K961 Ubiquitination PhosphoSitePlus
K990 Acetylation PhosphoSitePlus   UniProt 19608861
K998 Acetylation PhosphoSitePlus
K1000 Acetylation PhosphoSitePlus
K1009 Acetylation PhosphoSitePlus
T1018 Phosphorylation PhosphoSitePlus
S1020 Phosphorylation PhosphoSitePlus
K1034 Ubiquitination PhosphoSitePlus
T1089 O-Glycosylation GlyGen 30379171, 29208956
K1248 Ubiquitination PhosphoSitePlus
S1260 Phosphorylation PhosphoSitePlus
K1277 Ubiquitination PhosphoSitePlus
S1289 Phosphorylation PhosphoSitePlus
K1294 Ubiquitination PhosphoSitePlus
T1295 Phosphorylation PhosphoSitePlus
T1299 Phosphorylation PhosphoSitePlus
T1300 Phosphorylation PhosphoSitePlus
K1341 Ubiquitination PhosphoSitePlus
K1345 Ubiquitination PhosphoSitePlus
T1347 Phosphorylation PhosphoSitePlus
S1363 Phosphorylation PhosphoSitePlus
S1414 Phosphorylation PhosphoSitePlus
S1482 Phosphorylation PhosphoSitePlus
S1486 Phosphorylation PhosphoSitePlus
S1488 Phosphorylation PhosphoSitePlus
S1493 Phosphorylation PhosphoSitePlus
S1587 Phosphorylation PhosphoSitePlus
S1651 Phosphorylation PhosphoSitePlus
S1660 O-Glycosylation GlyGen 30379171, 29208956
S1660 Phosphorylation PhosphoSitePlus
S1667 Phosphorylation PhosphoSitePlus
K1671 Ubiquitination PhosphoSitePlus
S1683 Phosphorylation PhosphoSitePlus
T1687 Phosphorylation PhosphoSitePlus
S1745 Phosphorylation PhosphoSitePlus
K1866 Ubiquitination PhosphoSitePlus
T1940 Phosphorylation PhosphoSitePlus
T2161 Phosphorylation PhosphoSitePlus
T2179 Phosphorylation PhosphoSitePlus
S2267 Phosphorylation PhosphoSitePlus
S2311 Phosphorylation PhosphoSitePlus
S2313 Phosphorylation PhosphoSitePlus
C2386 Methylation IEDB 31844290
S2397 Phosphorylation PhosphoSitePlus
Y2412 Phosphorylation PhosphoSitePlus
K2417 Ubiquitination PhosphoSitePlus
T2430 Phosphorylation PhosphoSitePlus
T2471 Phosphorylation PhosphoSitePlus
S2511 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S176 Phosphorylation HPRD 18691976
S1260 Phosphorylation HPRD 18452278
S1651 Phosphorylation HPRD 19007248


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S23 G23 Biomuta DOID:1324 / lung cancer [ cosmic ]
S176 C176 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K475 M475 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S925 F925 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1289 Y1289 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S1289 C1289 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T1347 I1347 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1660 L1660 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S1660 * Biomuta DOID:10534 / stomach cancer [ cosmic ]
K1671 N1671 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1671 T1671 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1745 F1745 Biomuta DOID:4159 / skin cancer [ cosmic ]