iPTMnet Report for O75390 (CS)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O75390 / CISY_HUMAN
Protein Name Citrate synthase, mitochondrial precursor
Gene Name Name: CS
Organism Homo sapiens (Human)

PRO ID PR:O75390
DAG View
PRO Name citrate synthase, mitochondrial (human)
Definition A citrate synthase, mitochondrial that is encoded in the genome of human.
Short Label hCS
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75390 (CS) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T5 Phosphorylation HPRD   PhosphoSitePlus 20068231
T13 Phosphorylation HPRD   PhosphoSitePlus 20068231
K43 Acetylation PhosphoSitePlus
K43 Ubiquitination PhosphoSitePlus
K76 Acetylation PhosphoSitePlus
K76 Ubiquitination PhosphoSitePlus
Y80 Phosphorylation PhosphoSitePlus
T82 Phosphorylation PhosphoSitePlus
S83 Phosphorylation PhosphoSitePlus
S97 Phosphorylation PhosphoSitePlus
C101 S-Nitrosylation dbSNO 2212679, 22126794
K103 Acetylation PhosphoSitePlus
K103 Ubiquitination PhosphoSitePlus
Y185 Phosphorylation PhosphoSitePlus
S190 Phosphorylation PhosphoSitePlus
K193 Acetylation PhosphoSitePlus
C211 S-Nitrosylation dbSNO 19483679, 20140087, 22178444
K215 Acetylation PhosphoSitePlus
K215 Ubiquitination PhosphoSitePlus
K321 Acetylation PhosphoSitePlus
K327 Acetylation PhosphoSitePlus   UniProt 19608861
K327 Ubiquitination PhosphoSitePlus
Y331 Phosphorylation PhosphoSitePlus
S338 Phosphorylation PhosphoSitePlus
K366 Acetylation PhosphoSitePlus
K366 Ubiquitination PhosphoSitePlus
K375 Acetylation PhosphoSitePlus   UniProt 19608861
Y381 Phosphorylation PhosphoSitePlus
K382 Acetylation PhosphoSitePlus   UniProt 19608861
K382 Ubiquitination PhosphoSitePlus
K393 Acetylation PhosphoSitePlus   UniProt 19608861
K393 Ubiquitination PhosphoSitePlus
K395 Methylation PhosphoSitePlus
K450 Acetylation PhosphoSitePlus
S451 Phosphorylation PhosphoSitePlus
K459 Acetylation PhosphoSitePlus
K459 Ubiquitination PhosphoSitePlus
S463 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K215 N215 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K459 E459 Biomuta DOID:363 / uterine cancer [ icgc ]
S463 F463 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]