iPTMnet Report for O75385 (ULK1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O75385 / ULK1_HUMAN
Protein Name Serine/threonine-protein kinase ULK1
Gene Name Name: ULK1
Synonyms:KIAA0722;
Organism Homo sapiens (Human)

PRO ID PR:O75385
DAG View
PRO Name serine/threonine-protein kinase ULK1 (human)
Definition A serine/threonine-protein kinase ULK1 that is encoded in the genome of human.
Short Label hULK1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75385 (ULK1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K13 Ubiquitination PhosphoSitePlus
K46 Ubiquitination PhosphoSitePlus
C47 Methylation IEDB 31844290
K55 Ubiquitination PhosphoSitePlus
T58 Phosphorylation PhosphoSitePlus
K62 Ubiquitination PhosphoSitePlus
K68 Acetylation PhosphoSitePlus
S111 Phosphorylation PhosphoSitePlus
S131 Phosphorylation PhosphoSitePlus
K140 Ubiquitination PhosphoSitePlus
S158 Phosphorylation PhosphoSitePlus
K162 Acetylation PhosphoSitePlus
K162 Ubiquitination PhosphoSitePlus
T180 Phosphorylation O75385 (ULK1) PRO   RLIMS-P+   RLIMS-P 35758243, 21819378
S225 Phosphorylation PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
K237 Ubiquitination PhosphoSitePlus
S281 Phosphorylation PhosphoSitePlus
S307 Phosphorylation RLIMS-P 28821724
S317 Phosphorylation P54646 (PRKAA2) , Q13131 (PRKAA1) neXtProt   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 32693121, 29321306, 25957282, ...27869123, 28978086, 25891078, 34604061, 28146421, 23372762, 30024813, 27903966, 29208687, 27935582, 26734992, 28401008, 29233105, 23878245, 24705402, 21205641, 19584320, 33898322, 29156790, 21258367
S330 Phosphorylation PhosphoSitePlus
S403 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 33654220, 23186163
S405 Phosphorylation PhosphoSitePlus   RLIMS-P 33654220
S409 O-Glycosylation GlyGen   PhosphoSitePlus 30517873, 35931119, 28903979
S409 Phosphorylation PhosphoSitePlus   RLIMS-P 33654220
S410 O-Glycosylation PhosphoSitePlus
S411 Phosphorylation RLIMS-P 33654220
S415 Phosphorylation PhosphoSitePlus   RLIMS-P 33654220
S423 Phosphorylation PhosphoSitePlus   RLIMS-P 30154410, 35931119
S429 Phosphorylation PhosphoSitePlus
S450 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...19664994, 18669648, 19690332, 20068231
T456 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S459 Phosphorylation HPRD   PhosphoSitePlus 20068231
S460 Phosphorylation HPRD   PhosphoSitePlus 20068231
S465 Phosphorylation HPRD   PhosphoSitePlus 19651622
S467 Phosphorylation HPRD   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 22498478, 18669648, 23186163, ...25043686
T468 Phosphorylation PhosphoSitePlus
S469 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 31378785, 19651622, ...18669648, 23186163
S477 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 23186163
S479 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 23186163
S495 Phosphorylation PhosphoSitePlus   RLIMS-P 31378785
S522 Phosphorylation PhosphoSitePlus
R529 Methylation PhosphoSitePlus
S533 Phosphorylation PhosphoSitePlus   RLIMS-P 31378785
S538 Phosphorylation PhosphoSitePlus
S539 Phosphorylation PhosphoSitePlus
S544 Phosphorylation PhosphoSitePlus
S556 Phosphorylation P54646 (PRKAA2) HPRD   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19584320, 29563162, 23186163, ...17081983, 21406692, 34421918, 21205641, 25891078, 24767988, 18669648, 30093610, 33037394, 28806404, 32168879
S561 Phosphorylation PhosphoSitePlus
T575 Phosphorylation PRO   PhosphoSitePlus
S583 Phosphorylation PhosphoSitePlus
S588 Phosphorylation PhosphoSitePlus
S593 Phosphorylation PhosphoSitePlus
S598 Phosphorylation PhosphoSitePlus
S605 Phosphorylation PhosphoSitePlus
K607 Acetylation PhosphoSitePlus
S623 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18691976, 18669648, 20068231
T625 Phosphorylation HPRD   PhosphoSitePlus 20068231
S630 Phosphorylation PhosphoSitePlus
T636 Phosphorylation HPRD   PhosphoSitePlus 17322306
S638 Phosphorylation P42345 (MTOR) , Q13131 (PRKAA1) , P54646 (PRKAA2) HPRD   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19584320, 21406692, 23186163, ...18220336, 18767875, 21383122, 21205641, 17192257, 17322306, 18669648, 30093610, 19690332, 20068231
S639 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
T654 Phosphorylation PhosphoSitePlus
T660 Phosphorylation PhosphoSitePlus
S665 Phosphorylation PhosphoSitePlus
S694 Phosphorylation PhosphoSitePlus
T695 Phosphorylation PhosphoSitePlus
T699 Phosphorylation PhosphoSitePlus
T709 Phosphorylation PhosphoSitePlus
S716 Phosphorylation PhosphoSitePlus
T717 Phosphorylation HPRD   PhosphoSitePlus 19413330
S719 Phosphorylation PhosphoSitePlus
S748 Phosphorylation PhosphoSitePlus
T755 O-Glycosylation GlyGen   PhosphoSitePlus 30517873
S758 Phosphorylation P42345 (MTOR) HPRD   neXtProt   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 29563162, 23186163, 16964243, ...31733992, 21258367, 33916918, 30410117, 21205641, 30093610, 27731364, 21383122, 32168879
S761 Phosphorylation PhosphoSitePlus
T764 Phosphorylation PhosphoSitePlus
S775 Phosphorylation PhosphoSitePlus   UniProt 23186163
S781 Phosphorylation PhosphoSitePlus
S949 Phosphorylation PhosphoSitePlus
S954 Phosphorylation PhosphoSitePlus
S1042 Phosphorylation PhosphoSitePlus
T1046 Phosphorylation PhosphoSitePlus


O75385 (ULK1) as PTM Enzyme



Substrate Site Score Source PMID
A2RUS2 (DENND3) S472 PhosphoSitePlus   Signor 25925668
A2RUS2 (DENND3) S490 PhosphoSitePlus   Signor 25925668
O00560 (SDCBP) S6 PhosphoSitePlus 21949238
O75143 (ATG13) S355 PhosphoSitePlus 26138443, 21855797
O75385 (ULK1) T180 RLIMS-P+ 21819378
Q13131 (PRKAA1) S360 neXtProt 21460634
Q13131 (PRKAA1) T368 neXtProt 21460634
Q13131 (PRKAA1) S397 neXtProt 21460634
Q13131 (PRKAA1) S486 neXtProt 21460634
Q13131 (PRKAA1) T488 neXtProt 21460634
Q15437 (SEC23B) S186 Signor 30596474
Q7Z3C6 (ATG9A) S14 Signor 27934868
Q7Z3C6 (ATG9A) S761 PhosphoSitePlus   Signor 25266655
Q86WV6 (STING1) S366 PhosphoSitePlus 24119841
Q8IVP5 (FUNDC1) S17 Signor 24671035
Q8N122 (RPTOR) S792 PhosphoSitePlus 21460630
Q8N122 (RPTOR) S855 PhosphoSitePlus 21460630
Q8N122 (RPTOR) S859 PhosphoSitePlus 21460630


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049613 (hULK1/Phos:1) pS317,pS467,pS556,pT575,pS638 PRO
PR:000049614 (hULK1/Phos:2) pS758 PRO
PR:000049615 (hULK1/Phos:3) pT180,pS317,pS467,pS556,pT575,pS638 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O75385 (ULK1) S758 P54646 (PRKAA2) unknown eFIP 21383122
Phosphorylation O75385 (ULK1) S405 Q9GZQ8 (MAP1LC3B) unknown eFIP 33654220
Phosphorylation O75385 (ULK1) S405 P49841 (GSK3B) unknown eFIP 33654220
Phosphorylation O75385 (ULK1) S405 Q9H0R8 (GABARAPL1) unknown eFIP 33654220


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
C47 R47 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S317 F317 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S330 F330 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S403 F403 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S459 P459 Biomuta DOID:363 / uterine cancer [ icgc ]
S460 C460 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S479 L479 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R529 Q529 Biomuta DOID:4159 / skin cancer [ cosmic ]
R529 L529 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S538 F538 Biomuta DOID:4159 / skin cancer [ cosmic ]
S544 C544 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:4362 / cervical cancer [ cosmic, icgc ]
S556 I556 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T575 M575 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T575 P575 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S598 P598 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S623 F623 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T625 I625 Biomuta DOID:4159 / skin cancer [ cosmic ]
S630 F630 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S630 Y630 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T636 A636 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T654 M654 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T660 M660 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T695 A695 Biomuta DOID:4159 / skin cancer [ cosmic ]
T717 M717 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T755 I755 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
S775 L775 Biomuta DOID:4159 / skin cancer [ cosmic ]
S775 P775 Biomuta DOID:363 / uterine cancer [ icgc ]
S954 N954 Biomuta DOID:9256 / colorectal cancer [ cosmic ]