Protein Information

Cytoscape View


UniProt AC / UniProt ID O75367 / H2AY_HUMAN
Protein Name Core histone macro-H2A.1
Gene Name Name: H2AFY
Synonyms:MACROH2A1;
Organism Homo sapiens (Human)

PRO ID PR:O75367
DAG View
PRO Name core histone macro-H2A.1 (human)
Definition A core histone macro-H2A.1 that is encoded in the genome of human.
Short Label hH2AFY
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75367 (H2AFY) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K7 Acetylation PhosphoSitePlus
K12 Acetylation PhosphoSitePlus
K18 Acetylation PhosphoSitePlus
K18 Methylation PhosphoSitePlus   UniProt 16210244
K18 Ubiquitination PhosphoSitePlus
R27 Methylation PhosphoSitePlus
Y55 Phosphorylation PhosphoSitePlus
K96 Ubiquitination PhosphoSitePlus
S102 Phosphorylation PhosphoSitePlus
K116 Ubiquitination PhosphoSitePlus   UniProt 16129414
K117 Ubiquitination PhosphoSitePlus   UniProt 16129414
S120 Phosphorylation PhosphoSitePlus
K121 Ubiquitination PhosphoSitePlus
K123 Acetylation PhosphoSitePlus
K123 Methylation PhosphoSitePlus   UniProt 16210244
K123 Ubiquitination PhosphoSitePlus
T129 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 16210244, 19690332, 20068231, 17924679
S138 Phosphorylation PRO   PhosphoSitePlus 18227505
S140 Phosphorylation PhosphoSitePlus
S146 Phosphorylation PhosphoSitePlus
K153 Acetylation PhosphoSitePlus
S158 Phosphorylation PhosphoSitePlus
K159 Acetylation PhosphoSitePlus
S166 Phosphorylation PhosphoSitePlus
K167 Ubiquitination PhosphoSitePlus
S170 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...19690332
S173 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332
T174 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T175 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T178 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18669648, ...19690332, 20068231
T188 Phosphorylation PhosphoSitePlus
K189 Ubiquitination PhosphoSitePlus
K196 Ubiquitination PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
K239 Methylation PhosphoSitePlus
R249 Methylation PhosphoSitePlus
K251 Ubiquitination PhosphoSitePlus
K271 Ubiquitination PhosphoSitePlus
S278 Phosphorylation PhosphoSitePlus
K285 Acetylation PhosphoSitePlus
K285 Ubiquitination PhosphoSitePlus
K292 Acetylation PhosphoSitePlus
K292 Ubiquitination PhosphoSitePlus
K295 Ubiquitination PhosphoSitePlus
K304 Acetylation PhosphoSitePlus
K304 Ubiquitination PhosphoSitePlus
K307 Ubiquitination PhosphoSitePlus
S308 Phosphorylation PhosphoSitePlus
S313 Phosphorylation PhosphoSitePlus
S316 Phosphorylation PhosphoSitePlus
K323 Ubiquitination PhosphoSitePlus
T325 Phosphorylation PhosphoSitePlus
K332 Ubiquitination PhosphoSitePlus
Y362 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T129 Phosphorylation HPRD 19413330, 16210244, 18077418, ...19007248, 19691289, 19651622, 18669648, 17924679, 20068231, 20068230
S138 Phosphorylation HPRD 18077418
S140 Phosphorylation HPRD 18077418
S170 Phosphorylation HPRD 19413330, 18669648, 19007248, ...20068231, 18452278
S173 Phosphorylation HPRD 19413330, 18669648, 19007248, ...18452278
T174 Phosphorylation HPRD 18669648, 19007248, 20068231, ...18452278
T175 Phosphorylation HPRD 18669648
T178 Phosphorylation HPRD 18669648, 17081983, 20068231
Site PTM Type PTM Enzyme Score Source PMID
T129 Phosphorylation HPRD 19413330, 16210244, 18077418, ...19007248, 19691289, 19651622, 18669648, 17924679, 20068231, 20068230
S138 Phosphorylation HPRD 18077418
S140 Phosphorylation HPRD 18077418
S170 Phosphorylation HPRD 19413330, 18669648, 19007248, ...20068231, 18452278
S173 Phosphorylation HPRD 19413330, 18669648, 19007248, ...18452278
T174 Phosphorylation HPRD 18669648, 19007248, 20068231, ...18452278
T175 Phosphorylation HPRD 18669648
T178 Phosphorylation HPRD 18669648, 17081983, 20068231
Site PTM Type PTM Enzyme Score Source PMID
T129 Phosphorylation HPRD 19413330, 16210244, 18077418, ...19007248, 19691289, 19651622, 18669648, 17924679, 20068231, 20068230
S138 Phosphorylation HPRD 18077418
S140 Phosphorylation HPRD 18077418
S169 Phosphorylation HPRD 19413330, 18669648, 19007248, ...20068231, 18452278
S172 Phosphorylation HPRD 19413330, 18669648, 19007248, ...18452278
T173 Phosphorylation HPRD 18669648, 19007248, 20068231, ...18452278
T174 Phosphorylation HPRD 18669648
T177 Phosphorylation HPRD 18669648, 17081983, 20068231


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000044867 (hH2AFY/InitMet-/Phos:1) pS138 PRO 18227505


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R27 L27 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
R27 W27 Biomuta DOID:363 / uterine cancer [ tcga ]
Y55 * Biomuta DOID:3571 / liver cancer [ icgc ]
S102 N102 Biomuta DOID:1324 / lung cancer [ cosmic ]
S146 Y146 Biomuta DOID:363 / uterine cancer [ tcga ]
S166 G166 Biomuta DOID:263 / kidney cancer [ cosmic ]
S173 I173 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
T175 N175 Biomuta DOID:3571 / liver cancer [ icgc ]
T175 I175 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
T188 I188 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K251 N251 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S316 C316 Biomuta DOID:1612 / breast cancer [ cosmic ]