iPTMnet Report for O75197 (LRP5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O75197 / LRP5_HUMAN
Protein Name Low-density lipoprotein receptor-related protein 5 precursor
Gene Name Name: LRP5
Synonyms:LR3;
Organism Homo sapiens (Human)

PRO ID PR:O75197
DAG View
PRO Name low-density lipoprotein receptor-related protein 5 (human)
Definition A low-density lipoprotein receptor-related protein 5 that is encoded in the genome of human.
Short Label hLRP5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75197 (LRP5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K121 Ubiquitination PhosphoSitePlus
N138 N-Glycosylation GlyGen 23090970, 29741879, 24190977
K143 Ubiquitination PhosphoSitePlus
T185 Phosphorylation PhosphoSitePlus
K592 Ubiquitination PhosphoSitePlus
K802 Ubiquitination PhosphoSitePlus
K980 Ubiquitination PhosphoSitePlus
S1138 Phosphorylation PhosphoSitePlus
S1142 Phosphorylation PhosphoSitePlus
K1231 Ubiquitination PhosphoSitePlus
Y1473 Phosphorylation PhosphoSitePlus
T1492 Phosphorylation PhosphoSitePlus
Y1494 Phosphorylation PhosphoSitePlus
S1503 Phosphorylation PhosphoSitePlus
Y1528 Phosphorylation PhosphoSitePlus
Y1531 Phosphorylation PhosphoSitePlus
Y1552 Phosphorylation PhosphoSitePlus
K1561 Ubiquitination PhosphoSitePlus
S1589 Phosphorylation PhosphoSitePlus
S1593 Phosphorylation PhosphoSitePlus
S1615 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N138 S138 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y1494 S1494 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S1503 F1503 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]