iPTMnet Report for O75185 (ATP2C2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O75185 / AT2C2_HUMAN
Protein Name Calcium-transporting ATPase type 2C member 2
Gene Name Name: ATP2C2
Synonyms:KIAA0703,SPCA2;
Organism Homo sapiens (Human)

PRO ID PR:O75185
DAG View
PRO Name calcium-transporting ATPase type 2C member 2 (human)
Definition A calcium-transporting ATPase type 2C member 2 that is encoded in the genome of human.
Short Label hATP2C2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75185 (ATP2C2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T146 Phosphorylation PhosphoSitePlus
Y153 Phosphorylation PhosphoSitePlus
T264 Phosphorylation PhosphoSitePlus   UniProt 18669648
S267 Phosphorylation PhosphoSitePlus   UniProt 18669648
S268 Phosphorylation PhosphoSitePlus   UniProt 18669648
S290 Phosphorylation PhosphoSitePlus
S329 Phosphorylation PhosphoSitePlus
T346 Phosphorylation PhosphoSitePlus
K363 Acetylation PhosphoSitePlus
K380 Acetylation PhosphoSitePlus
T457 Phosphorylation PhosphoSitePlus
S471 Phosphorylation PhosphoSitePlus
S487 Phosphorylation PhosphoSitePlus
T600 Phosphorylation PhosphoSitePlus
T606 Phosphorylation PhosphoSitePlus
K634 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T146 I146 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
T264 R264 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T346 M346 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:263 / kidney cancer [ cosmic, icgc ]
T600 M600 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K634 R634 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K634 * Biomuta DOID:3571 / liver cancer [ cosmic ]