iPTMnet Report for O75175 (CNOT3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O75175 / CNOT3_HUMAN
Protein Name CCR4-NOT transcription complex subunit 3
Gene Name Name: CNOT3
Synonyms:KIAA0691,LENG2,NOT3;
Organism Homo sapiens (Human)

PRO ID PR:O75175
DAG View
PRO Name CCR4-NOT transcription complex subunit 3 (human)
Definition A CCR4-NOT transcription complex subunit 3 that is encoded in the genome of human.
Short Label hCNOT3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75175 (CNOT3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
C14 Methylation IEDB 31844290
K41 Ubiquitination PhosphoSitePlus
K82 Ubiquitination PhosphoSitePlus
T100 Phosphorylation HPRD 20068231
S104 Phosphorylation HPRD   PhosphoSitePlus 20068231
K105 Ubiquitination PhosphoSitePlus
S194 Phosphorylation HPRD   PhosphoSitePlus 20230923
S245 Phosphorylation PhosphoSitePlus
S291 Phosphorylation PhosphoSitePlus
T292 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
S294 Phosphorylation HPRD   PhosphoSitePlus 18212344, 19415658
S297 Phosphorylation PhosphoSitePlus
S299 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19651622, 21406692, 15302935, ...18691976
S467 Phosphorylation PhosphoSitePlus
T468 Phosphorylation PhosphoSitePlus
S469 Phosphorylation PhosphoSitePlus
S506 Phosphorylation PhosphoSitePlus
S507 Phosphorylation HPRD 18691976
S529 O-Glycosylation GlyGen 34019948, 35254053
S541 Phosphorylation PhosphoSitePlus
S542 Phosphorylation PhosphoSitePlus   UniProt 24275569
R635 Methylation PhosphoSitePlus
T645 Phosphorylation PhosphoSitePlus
Y685 Phosphorylation PhosphoSitePlus
K689 Ubiquitination PhosphoSitePlus
K737 Ubiquitination PhosphoSitePlus
Y746 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
C14 Y14 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S104 V104 Biomuta DOID:4159 / skin cancer [ cosmic ]
R635 Q635 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ]
T645 P645 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T645 M645 Biomuta DOID:2531 / hematologic cancer [ cosmic ]