iPTMnet Report for O75167 (PHACTR2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O75167 / PHAR2_HUMAN
Protein Name Phosphatase and actin regulator 2
Gene Name Name: PHACTR2
Synonyms:C6orf56,KIAA0680;
Organism Homo sapiens (Human)

PRO ID PR:O75167
DAG View
PRO Name phosphatase and actin regulator 2 (human)
Definition A phosphatase and actin regulator 2 that is encoded in the genome of human.
Short Label hPHACTR2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75167 (PHACTR2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
D2 Myristoylation UniProt 25807930
S16 Phosphorylation PhosphoSitePlus   UniProt 23186163
T20 Phosphorylation PhosphoSitePlus
S23 Phosphorylation PhosphoSitePlus
T25 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
K29 Methylation PhosphoSitePlus
K31 Methylation PhosphoSitePlus
S59 Phosphorylation PhosphoSitePlus
S67 Phosphorylation PhosphoSitePlus
T129 Phosphorylation PhosphoSitePlus
T197 Phosphorylation PhosphoSitePlus
S237 Phosphorylation PhosphoSitePlus
S239 Phosphorylation PhosphoSitePlus
T276 Phosphorylation PhosphoSitePlus
S302 Phosphorylation PhosphoSitePlus
T384 Phosphorylation PhosphoSitePlus
Y386 Phosphorylation PhosphoSitePlus
S443 Phosphorylation PhosphoSitePlus
S445 Phosphorylation PhosphoSitePlus
T452 Phosphorylation PhosphoSitePlus
S464 Phosphorylation PhosphoSitePlus
T478 Phosphorylation PhosphoSitePlus
S522 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983
T527 Phosphorylation PhosphoSitePlus
K537 Ubiquitination PhosphoSitePlus
S556 Phosphorylation PhosphoSitePlus
S560 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y579 Phosphorylation PhosphoSitePlus
S585 Phosphorylation PhosphoSitePlus
K604 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S16 Phosphorylation HPRD 19651622
T25 Phosphorylation HPRD 19413330, 19651622, 19664994
S522 Phosphorylation HPRD 18077418, 17081983
Site PTM Type PTM Enzyme Score Source PMID
S5 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
D2 N2 Biomuta DOID:3571 / liver cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S5 L5 Biomuta DOID:4159 / skin cancer [ cosmic ]
T25 R25 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S59 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S59 L59 Biomuta DOID:4159 / skin cancer [ cosmic ]
S67 F67 Biomuta DOID:4159 / skin cancer [ cosmic ]
S237 L237 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
S237 A237 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S522 I522 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S556 R556 Biomuta DOID:1612 / breast cancer [ cosmic ]