iPTMnet Report for O75164 (KDM4A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O75164 / KDM4A_HUMAN
Protein Name Lysine-specific demethylase 4A
Gene Name Name: KDM4A
Synonyms:JHDM3A,JMJD2,JMJD2A,KIAA0677;
Organism Homo sapiens (Human)

PRO ID PR:O75164
DAG View
PRO Name lysine-specific demethylase 4A (human)
Definition A lysine-specific demethylase 4A that is encoded in the genome of human.
Short Label hKDM4A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75164 (KDM4A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Ubiquitination PRO
A2 Acetylation UniProt 19413330
T7 Phosphorylation PhosphoSitePlus
S11 Phosphorylation PhosphoSitePlus
T16 Phosphorylation PhosphoSitePlus
K51 Ubiquitination PhosphoSitePlus
K105 Ubiquitination PhosphoSitePlus
K143 Ubiquitination PhosphoSitePlus
T155 Phosphorylation PhosphoSitePlus
K224 Ubiquitination PhosphoSitePlus
K241 Acetylation PhosphoSitePlus
K251 Acetylation PhosphoSitePlus
K251 Ubiquitination PhosphoSitePlus
K252 Ubiquitination PhosphoSitePlus
K301 Ubiquitination PhosphoSitePlus
K336 Ubiquitination PhosphoSitePlus
K355 Ubiquitination PhosphoSitePlus
K386 Ubiquitination PhosphoSitePlus
S410 Phosphorylation PhosphoSitePlus
T452 Phosphorylation PhosphoSitePlus
K468 Ubiquitination PhosphoSitePlus
K471 Sumoylation PhosphoSitePlus
S502 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K505 Acetylation PhosphoSitePlus
S514 Phosphorylation PhosphoSitePlus
S516 Phosphorylation PhosphoSitePlus
S517 Phosphorylation PhosphoSitePlus
S520 Phosphorylation PhosphoSitePlus
S523 Phosphorylation PhosphoSitePlus   UniProt 23186163
C533 Methylation IEDB 31844290
C533 S-Nitrosylation dbSNO 26338901
Y547 Phosphorylation phospho.ELM   PhosphoSitePlus 16094384
S616 Phosphorylation PhosphoSitePlus
K820 Ubiquitination PhosphoSitePlus
K885 Ubiquitination PhosphoSitePlus
K893 Sumoylation PhosphoSitePlus
K893 Ubiquitination PhosphoSitePlus
S898 Phosphorylation PhosphoSitePlus
T900 Phosphorylation PhosphoSitePlus
K904 Ubiquitination PhosphoSitePlus
C917 Methylation IEDB 31844290
K1012 Ubiquitination PhosphoSitePlus
S1019 Phosphorylation PhosphoSitePlus
K1033 Ubiquitination PhosphoSitePlus
Y1053 Phosphorylation PhosphoSitePlus
Y1059 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S502 Phosphorylation HPRD 18669648
S523 Phosphorylation HPRD 18452278
Y547 Phosphorylation HPRD 16094384


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048094 (hKDM4A/UbiqLys+) ub PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 T2 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K301 T301 Biomuta DOID:1612 / breast cancer [ cosmic ]
K885 T885 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1012 R1012 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
Y1053 * Biomuta DOID:3571 / liver cancer [ cosmic ]