iPTMnet Report for O75161 (NPHP4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O75161 / NPHP4_HUMAN
Protein Name Nephrocystin-4
Gene Name Name: NPHP4
Synonyms:KIAA0673;
Organism Homo sapiens (Human)

PRO ID PR:O75161
DAG View
PRO Name nephrocystin-4 (human)
Definition A nephrocystin-4 that is encoded in the genome of human.
Short Label hNPHP4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75161 (NPHP4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
C56 Methylation IEDB 31844290
S142 Phosphorylation PhosphoSitePlus   UniProt 23186163
K150 Ubiquitination PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
T315 Phosphorylation PhosphoSitePlus
S319 Phosphorylation PhosphoSitePlus
S321 Phosphorylation PhosphoSitePlus
K329 Ubiquitination PhosphoSitePlus
S331 Phosphorylation PhosphoSitePlus
Y423 Phosphorylation IEDB 35494241
K424 Ubiquitination PhosphoSitePlus
K436 Ubiquitination PhosphoSitePlus
S451 Phosphorylation PhosphoSitePlus
T477 Phosphorylation PhosphoSitePlus
S478 Phosphorylation PhosphoSitePlus
S480 Phosphorylation PhosphoSitePlus
S481 Phosphorylation PhosphoSitePlus
S496 Phosphorylation PhosphoSitePlus
S510 Phosphorylation PhosphoSitePlus
S513 Phosphorylation PhosphoSitePlus
C518 Methylation IEDB 31844290
K731 Ubiquitination PhosphoSitePlus
K809 Ubiquitination PhosphoSitePlus
K818 Ubiquitination PhosphoSitePlus
K835 Ubiquitination PhosphoSitePlus
S847 Phosphorylation PhosphoSitePlus
K879 Ubiquitination PhosphoSitePlus
K899 Ubiquitination PhosphoSitePlus
S943 Phosphorylation PhosphoSitePlus
K1027 Ubiquitination PhosphoSitePlus
K1086 Ubiquitination PhosphoSitePlus
K1095 Ubiquitination PhosphoSitePlus
K1197 Ubiquitination PhosphoSitePlus
S1203 Phosphorylation PhosphoSitePlus
S1215 Phosphorylation PhosphoSitePlus
K1332 Ubiquitination PhosphoSitePlus
Y1352 Phosphorylation PhosphoSitePlus
S1358 Phosphorylation PhosphoSitePlus
S1378 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S480 L480 Biomuta DOID:4159 / skin cancer [ cosmic ]
S481 I481 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
C518 Y518 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K1086 N1086 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S1203 R1203 Biomuta DOID:3571 / liver cancer [ cosmic ]
S1215 P1215 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S1378 T1378 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1378 F1378 Biomuta DOID:4159 / skin cancer [ cosmic ]