Protein Information

Cytoscape View


UniProt AC / UniProt ID O75157 / T22D2_HUMAN
Protein Name TSC22 domain family protein 2
Gene Name Name: TSC22D2
Synonyms:KIAA0669,TILZ4;
Organism Homo sapiens (Human)

PRO ID PR:O75157
DAG View
PRO Name TSC22 domain family protein 2 (human)
Definition A TSC22 domain family protein 2 that is encoded in the genome of human.
Short Label hTSC22D2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75157 (TSC22D2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y57 Phosphorylation PhosphoSitePlus
C63 S-Nitrosylation dbSNO 26338901
S171 Phosphorylation PhosphoSitePlus
T181 Phosphorylation PhosphoSitePlus
S190 Phosphorylation PhosphoSitePlus
S192 Phosphorylation PhosphoSitePlus
S205 Phosphorylation PhosphoSitePlus
S206 Phosphorylation PhosphoSitePlus
T207 Phosphorylation PhosphoSitePlus
S548 O-Glycosylation GlyGen 23301498, 29351928
S550 O-Glycosylation GlyGen 23301498, 29351928
S550 Phosphorylation phospho.ELM 18669648
S551 O-Glycosylation GlyGen 23301498, 29351928
S552 O-Glycosylation GlyGen 23301498, 29351928
T570 O-Glycosylation GlyGen 23301498, 29351928
S571 O-Glycosylation GlyGen 23301498, 29351928
S575 O-Glycosylation GlyGen 23301498, 29351928
S598 Phosphorylation PhosphoSitePlus
S607 Phosphorylation PhosphoSitePlus
K698 Ubiquitination PhosphoSitePlus
Y703 Phosphorylation PhosphoSitePlus
K713 Ubiquitination PhosphoSitePlus
S724 Phosphorylation PhosphoSitePlus
S778 O-Glycosylation GlyGen 23301498, 29351928
S779 O-Glycosylation GlyGen 23301498, 29351928
Site PTM Type PTM Enzyme Score Source PMID
S550 Phosphorylation HPRD 18669648
S598 Phosphorylation HPRD 19413330


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S205 G205 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S206 I206 Biomuta DOID:363 / uterine cancer [ tcga ]
T207 A207 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
T570 R570 Biomuta DOID:1909 / melanoma [ cosmic ]
S724 C724 Biomuta DOID:1324 / lung cancer [ cosmic ]