Protein Information

Cytoscape View


UniProt AC / UniProt ID O75151 / PHF2_HUMAN
Protein Name Lysine-specific demethylase PHF2
Gene Name Name: PHF2
Synonyms:CENP-35;
Organism Homo sapiens (Human)

PRO ID PR:O75151
DAG View
PRO Name lysine-specific demethylase PHF2 (human)
Definition A lysine-specific demethylase PHF2 that is encoded in the genome of human.
Short Label hPHF2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75151 (PHF2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K80 Sumoylation PhosphoSitePlus
S86 Phosphorylation PhosphoSitePlus
T162 Phosphorylation HPRD 20068231
K175 Ubiquitination PhosphoSitePlus
K214 Ubiquitination PhosphoSitePlus
K382 Ubiquitination PhosphoSitePlus
K389 Ubiquitination PhosphoSitePlus
K412 Ubiquitination PhosphoSitePlus
K427 Ubiquitination PhosphoSitePlus
S458 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983
S459 Phosphorylation HPRD   PhosphoSitePlus 17081983
S474 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20068231, 24275569, 18452278
T479 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20068231, 18452278
S483 Phosphorylation PhosphoSitePlus
S534 Phosphorylation PhosphoSitePlus
S537 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
S539 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
T541 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 17081983
S612 Phosphorylation PhosphoSitePlus
S625 Phosphorylation HPRD   PhosphoSitePlus 20068231
K631 Methylation PhosphoSitePlus
S638 Phosphorylation PhosphoSitePlus
S640 Phosphorylation PhosphoSitePlus
K642 Methylation PhosphoSitePlus
K648 Ubiquitination PhosphoSitePlus
T654 Phosphorylation HPRD   PhosphoSitePlus 17081983, 20068231
S655 Phosphorylation P28482 (MAPK1) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 22028470, 23186163, 17081983, ...18669648, 20068231
Y677 Phosphorylation HPRD 17081983
S681 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20068231, 17081983, 24275569
S705 Phosphorylation HPRD   PhosphoSitePlus   UniProt 21406692, 23186163, 20068231
K720 Acetylation PhosphoSitePlus
S730 Phosphorylation PhosphoSitePlus
S733 Phosphorylation PhosphoSitePlus
S734 Phosphorylation PhosphoSitePlus
S738 Phosphorylation PhosphoSitePlus
T743 Phosphorylation PhosphoSitePlus
T745 Phosphorylation PhosphoSitePlus
S757 Phosphorylation PhosphoSitePlus
S771 Phosphorylation PhosphoSitePlus
S788 Phosphorylation PhosphoSitePlus
S853 Phosphorylation PhosphoSitePlus
S879 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S882 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 23186163, 17081983, ...18452278, 18669648, 24275569, 19690332, 20068231
S899 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18220336, 24275569, 18452278
Y904 Phosphorylation HPRD 17081983
S905 Phosphorylation HPRD   PhosphoSitePlus 17081983
T907 Phosphorylation PhosphoSitePlus
T925 Phosphorylation PhosphoSitePlus
S929 Phosphorylation O14757 (CHEK1) PhosphoSitePlus 21851590
S942 Phosphorylation PhosphoSitePlus
S954 Phosphorylation PhosphoSitePlus
S1056 Phosphorylation PhosphoSitePlus   UniProt 21532585
S1058 Phosphorylation PhosphoSitePlus
S1059 Phosphorylation HPRD   PhosphoSitePlus 20068231
T1064 Phosphorylation PhosphoSitePlus
K1072 Acetylation PhosphoSitePlus
K1079 Acetylation PhosphoSitePlus
K1087 Sumoylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S474 F474 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
T479 P479 Biomuta DOID:3963 / thyroid carcinoma [ cosmic ]
S681 L681 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S705 P705 Biomuta DOID:3070 / malignant glioma [ tcga ]
S1058 * Biomuta DOID:363 / uterine cancer [ tcga ]
T1064 I1064 Biomuta DOID:4362 / cervical cancer [ tcga ]