Protein Information

Cytoscape View


UniProt AC / UniProt ID O75150 / BRE1B_HUMAN
Protein Name E3 ubiquitin-protein ligase BRE1B
Gene Name Name: RNF40
Synonyms:BRE1B,KIAA0661;
Organism Homo sapiens (Human)

PRO ID PR:O75150
DAG View
PRO Name E3 ubiquitin-protein ligase BRE1B (human)
Definition An E3 ubiquitin-protein ligase BRE1B that is encoded in the genome of human.
Short Label hRNF40
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75150 (RNF40) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K7 Ubiquitination PhosphoSitePlus
K20 Acetylation PhosphoSitePlus
K21 Acetylation PhosphoSitePlus
K27 Ubiquitination PhosphoSitePlus
K50 Ubiquitination PhosphoSitePlus
K55 Ubiquitination PhosphoSitePlus
S114 Phosphorylation Q13315 (ATM) PhosphoSitePlus 21362549
T127 Phosphorylation PhosphoSitePlus
K189 Ubiquitination PhosphoSitePlus
R201 Methylation PhosphoSitePlus
K264 Ubiquitination PhosphoSitePlus
T277 Phosphorylation PhosphoSitePlus
T278 Phosphorylation PhosphoSitePlus
K355 Ubiquitination PhosphoSitePlus
K420 Ubiquitination PhosphoSitePlus
K439 Ubiquitination PhosphoSitePlus
T451 Phosphorylation PhosphoSitePlus
K457 Ubiquitination PhosphoSitePlus
K498 Ubiquitination PhosphoSitePlus
K517 Acetylation PhosphoSitePlus
K517 Ubiquitination PhosphoSitePlus
S523 Phosphorylation PhosphoSitePlus
S525 Phosphorylation PhosphoSitePlus
T529 Phosphorylation PhosphoSitePlus
S556 Phosphorylation PhosphoSitePlus
T557 Phosphorylation PhosphoSitePlus
K562 Acetylation PhosphoSitePlus
T571 Phosphorylation PhosphoSitePlus
T574 Phosphorylation PhosphoSitePlus
K578 Sumoylation PhosphoSitePlus
S585 Phosphorylation PhosphoSitePlus
T593 Phosphorylation PhosphoSitePlus
S600 Phosphorylation PhosphoSitePlus
S601 Phosphorylation PhosphoSitePlus
T644 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
K653 Ubiquitination PhosphoSitePlus
K686 Acetylation PhosphoSitePlus
K743 Ubiquitination PhosphoSitePlus
K788 Ubiquitination PhosphoSitePlus
K795 Methylation PhosphoSitePlus
K795 Ubiquitination PhosphoSitePlus
K801 Ubiquitination PhosphoSitePlus
K818 Ubiquitination PhosphoSitePlus
S819 Phosphorylation Q13315 (ATM) PhosphoSitePlus 17478428
K830 Ubiquitination PhosphoSitePlus
K847 Ubiquitination PhosphoSitePlus
S853 Phosphorylation Q13315 (ATM) PhosphoSitePlus 17478428
K874 Ubiquitination PhosphoSitePlus
K906 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T127 Phosphorylation HPRD 18077418
T644 Phosphorylation HPRD 17081983, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K20 N20 Biomuta DOID:9256 / colorectal cancer [ icgc ]
T277 I277 Biomuta DOID:4362 / cervical cancer [ tcga ] DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
T451 A451 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
K517 N517 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S556 I556 Biomuta DOID:3571 / liver cancer [ icgc ]
S585 F585 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K653 E653 Biomuta DOID:9256 / colorectal cancer [ tcga ]
K653 R653 Biomuta DOID:3963 / thyroid carcinoma [ cosmic ]