iPTMnet Report O75144 ICOSLG

Protein Information

Cytoscape View

UniProt AC / UniProt ID	O75144 / ICOSL_HUMAN
Protein Name	ICOS ligand precursor
Gene Name	Name: ICOSLG Synonyms:B7H2,B7RP1,ICOSL,KIAA0653;
Organism	Homo sapiens (Human)

PRO ID	PR:O75144 DAG View
PRO Name	ICOS ligand (human)
Definition	An ICOS ligand that is encoded in the genome of human.
Short Label	hICOSLG
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

O75144 (ICOSLG) as Substrate

Condensed View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	T56	Phosphorylation		score1	PhosphoSitePlus
	N70	N-Glycosylation		score2	GlyGen UniProt	16335952, 23090970, 30237853, ...24190977
	N102	N-Glycosylation		score1	GlyGen	23090970, 30237853, 24190977
	C113	Methylation		score1	IEDB	31844290
	N173	N-Glycosylation		score1	GlyGen	23090970, 24190977
	N186	N-Glycosylation		score2	GlyGen UniProt	16335952, 23090970, 24190977
	N225	N-Glycosylation		score1	GlyGen	23345538
	T243	O-Glycosylation		score1	GlyGen	32574038
	T249	O-Glycosylation		score1	GlyGen	32574038
	S285	Phosphorylation		score1	PhosphoSitePlus
	S293	Phosphorylation		score1	PhosphoSitePlus

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	N225	N-Glycosylation		score1	PRO	23345538

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
C113	Y113	Biomuta		DOID:4159 / skin cancer [ cosmic ]
N186	S186	Biomuta		DOID:1324 / lung cancer [ cosmic, icgc ]
S285	I285	Biomuta		DOID:9256 / colorectal cancer [ cosmic ]