iPTMnet Report for O75140 (DEPDC5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O75140 / DEPD5_HUMAN
Protein Name GATOR1 complex protein DEPDC5
Gene Name Name: DEPDC5
Synonyms:KIAA0645;
Organism Homo sapiens (Human)

PRO ID PR:O75140
DAG View
PRO Name GATOR complex protein DEPDC5 (human)
Definition A GATOR complex protein DEPDC5 that is encoded in the genome of human.
Short Label hDEPDC5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75140 (DEPDC5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T66 Phosphorylation PhosphoSitePlus
Y155 Phosphorylation PhosphoSitePlus
T273 Phosphorylation PhosphoSitePlus
K411 Methylation PhosphoSitePlus
S432 Phosphorylation PhosphoSitePlus
S445 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S489 Phosphorylation PhosphoSitePlus
S491 Phosphorylation PhosphoSitePlus
S494 Phosphorylation PhosphoSitePlus
S496 Phosphorylation PhosphoSitePlus
S497 Phosphorylation PhosphoSitePlus
S503 Phosphorylation PhosphoSitePlus
S505 Phosphorylation PhosphoSitePlus   UniProt 24275569
S508 Phosphorylation PhosphoSitePlus
T513 O-Glycosylation GlyGen 28657654
S521 Phosphorylation PhosphoSitePlus
S524 Phosphorylation PhosphoSitePlus
S525 Phosphorylation PhosphoSitePlus
S548 Phosphorylation PhosphoSitePlus
S579 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
T749 Phosphorylation PhosphoSitePlus
Y759 Phosphorylation PhosphoSitePlus
S831 Phosphorylation PhosphoSitePlus
S833 Phosphorylation PhosphoSitePlus
Y920 Phosphorylation PhosphoSitePlus
Y924 Phosphorylation PhosphoSitePlus
S1002 Phosphorylation UniProt 31548394
S1028 Phosphorylation PhosphoSitePlus
S1530 Phosphorylation PhosphoSitePlus   UniProt 31548394
T1531 Phosphorylation PhosphoSitePlus
Y1546 Phosphorylation PhosphoSitePlus
Y1550 Phosphorylation PhosphoSitePlus
K1574 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S445 Phosphorylation HPRD 18669648
S582 Phosphorylation HPRD 17081983
Y591 Phosphorylation HPRD 17081983
T592 Phosphorylation HPRD 17081983
S1081 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S445 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S491 T491 Biomuta [ cosmic ]
S497 F497 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
S505 F505 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S521 F521 Biomuta DOID:4159 / skin cancer [ cosmic ]
S521 T521 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S525 F525 Biomuta DOID:4159 / skin cancer [ cosmic ]
S548 F548 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y591 C591 Biomuta DOID:3571 / liver cancer [ cosmic ]
S1530 F1530 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y1546 S1546 Biomuta DOID:4159 / skin cancer [ cosmic ]