iPTMnet Report for O75128 (COBL)


Protein Information

Cytoscape View


UniProt AC / UniProt ID O75128 / COBL_HUMAN
Protein Name Protein cordon-bleu
Gene Name Name: COBL
Synonyms:KIAA0633;
Organism Homo sapiens (Human)

PRO ID PR:O75128
DAG View
PRO Name protein cordon-bleu (human)
Definition A protein cordon-bleu that is encoded in the genome of human.
Short Label hCOBL
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


O75128 (COBL) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S47 Phosphorylation PhosphoSitePlus
S77 Phosphorylation IEDB 35494241
K211 Ubiquitination PhosphoSitePlus
S212 Phosphorylation PhosphoSitePlus
S235 Phosphorylation PhosphoSitePlus
S258 Phosphorylation PhosphoSitePlus
S260 Phosphorylation PhosphoSitePlus
T265 Phosphorylation PhosphoSitePlus
T266 Phosphorylation PhosphoSitePlus
S269 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S271 Phosphorylation PhosphoSitePlus
S276 Phosphorylation PhosphoSitePlus
S282 Phosphorylation PhosphoSitePlus
S284 Phosphorylation PhosphoSitePlus
S287 Phosphorylation PhosphoSitePlus
S292 Phosphorylation PhosphoSitePlus
S295 Phosphorylation PhosphoSitePlus
S308 Phosphorylation PhosphoSitePlus
S321 Phosphorylation PhosphoSitePlus
S324 Phosphorylation PhosphoSitePlus   UniProt 23186163
S347 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T434 Phosphorylation PhosphoSitePlus
S440 Phosphorylation PhosphoSitePlus
T447 Phosphorylation PhosphoSitePlus
S455 Phosphorylation PhosphoSitePlus
S463 Phosphorylation PhosphoSitePlus
S566 Phosphorylation PhosphoSitePlus
S569 Phosphorylation PhosphoSitePlus
S574 Phosphorylation PhosphoSitePlus   UniProt 23186163
S578 Phosphorylation UniProt 24275569
S587 Phosphorylation PhosphoSitePlus
Y652 Phosphorylation PhosphoSitePlus
C654 Methylation IEDB 31844290
Y708 Phosphorylation PhosphoSitePlus
S741 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231, ...18220336
S751 Phosphorylation PhosphoSitePlus
K766 Ubiquitination PhosphoSitePlus
S775 Phosphorylation PhosphoSitePlus
T794 Phosphorylation PhosphoSitePlus
T798 Phosphorylation PhosphoSitePlus
S815 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231, ...24275569
S864 Phosphorylation PhosphoSitePlus
S865 Phosphorylation PhosphoSitePlus
Y867 Phosphorylation PhosphoSitePlus
Y891 Phosphorylation PhosphoSitePlus
K894 Ubiquitination PhosphoSitePlus
Y896 Phosphorylation PhosphoSitePlus
S917 Phosphorylation PhosphoSitePlus
T935 Phosphorylation PhosphoSitePlus
S962 Phosphorylation PhosphoSitePlus   UniProt 23186163
S974 Phosphorylation PhosphoSitePlus
S1000 Phosphorylation PhosphoSitePlus
T1026 Phosphorylation PhosphoSitePlus
S1027 Phosphorylation PhosphoSitePlus
S1142 Phosphorylation PhosphoSitePlus
Y1143 Phosphorylation PhosphoSitePlus
T1144 Phosphorylation PhosphoSitePlus
S1171 Phosphorylation PhosphoSitePlus
S1192 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1227 Phosphorylation PhosphoSitePlus   UniProt 23186163
Site PTM Type PTM Enzyme Score Source PMID
S347 Phosphorylation HPRD 18669648
S463 Phosphorylation HPRD 20068231
S741 Phosphorylation HPRD 18669648, 20068231
S751 Phosphorylation HPRD 15345747
S815 Phosphorylation HPRD 18669648, 20068231
Y896 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S268 Phosphorylation PhosphoSitePlus
S272 Phosphorylation PhosphoSitePlus
T291 Phosphorylation PhosphoSitePlus
S294 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S47 L47 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S77 G77 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S77 I77 Biomuta DOID:363 / uterine cancer [ icgc ]
S212 F212 Biomuta DOID:4159 / skin cancer [ cosmic ]
T266 I266 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S271 F271 Biomuta DOID:4159 / skin cancer [ cosmic ]
S287 I287 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S321 Y321 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S324 P324 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S324 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
T434 K434 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S455 G455 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S578 F578 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S741 G741 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S741 I741 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
S775 F775 Biomuta DOID:4159 / skin cancer [ cosmic ]
T794 S794 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
S815 L815 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic, icgc ]
S864 F864 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y891 C891 Biomuta DOID:3565 / meningioma [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
S962 C962 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
Y1143 C1143 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T1144 M1144 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]